Selective autoretroperfusion preserves myocardial function during coronary artery ligation in swine

Jenny S. Choy, Mark Svendsen, Xiao Lu, Hai Zheng, Matthew S. Sulkin, Anjan Sinha, Celina Morales, Issam Moussa, José A. Navia, Ghassan S. Kassab

Research output: Contribution to journalArticle

Abstract

Background: External pumps have been previously used to minimize edema and hemorrhage caused by coronary retroperfusion. The objective of this study was to use a pump-less approach (selective autoretroperfusion, SARP) to preserve myocardial function after acute coronary artery ligation. Methods: In five experimental pigs, the LAD artery was ligated distal to the first diagonal and retroperfusion was instituted for three hours from a brachiocephalic artery at 50 mmHg pressure through an adjustable occluder on the cannula. In eight control pigs, the LAD artery was ligated distal to the second diagonal for the same duration with no SARP. Results: ECG showed more prominent S-T segment elevation in the untreated control group despite the more distal ligation. The degree of myocardial contraction was significantly attenuated in the control group but was largely preserved in the SARP treated group. The myocytes were well preserved in the SARP group with no rupture of venous microvessels. Myocyte edema and disruption was observed in the control group with only mild extracellular edema in the SARP treated group. Conclusion: SARP preserved myocardial function with no damage to the myocyte and venules during three hours of acute LAD ligation.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalAcute Cardiac Care
Volume13
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Muscle Cells
Ligation
Edema
Coronary Vessels
Swine
Arteries
Control Groups
Myocardial Contraction
Venules
Microvessels
Rupture
Electrocardiography
Hemorrhage
Pressure
Cannula

Keywords

  • coronary veins
  • myocardial function
  • myocardial ischemia
  • Retrograde perfusion
  • retroperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Emergency Medicine

Cite this

Selective autoretroperfusion preserves myocardial function during coronary artery ligation in swine. / Choy, Jenny S.; Svendsen, Mark; Lu, Xiao; Zheng, Hai; Sulkin, Matthew S.; Sinha, Anjan; Morales, Celina; Moussa, Issam; Navia, José A.; Kassab, Ghassan S.

In: Acute Cardiac Care, Vol. 13, No. 2, 06.2011, p. 99-108.

Research output: Contribution to journalArticle

Choy, JS, Svendsen, M, Lu, X, Zheng, H, Sulkin, MS, Sinha, A, Morales, C, Moussa, I, Navia, JA & Kassab, GS 2011, 'Selective autoretroperfusion preserves myocardial function during coronary artery ligation in swine', Acute Cardiac Care, vol. 13, no. 2, pp. 99-108. https://doi.org/10.3109/17482941.2011.578748
Choy, Jenny S. ; Svendsen, Mark ; Lu, Xiao ; Zheng, Hai ; Sulkin, Matthew S. ; Sinha, Anjan ; Morales, Celina ; Moussa, Issam ; Navia, José A. ; Kassab, Ghassan S. / Selective autoretroperfusion preserves myocardial function during coronary artery ligation in swine. In: Acute Cardiac Care. 2011 ; Vol. 13, No. 2. pp. 99-108.
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