Selective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine

Sheketha R. Hauser, Amy L. Bracken, Gerald A. Deehan, Jamie E. Toalston, Zheng Ming Ding, William Truitt, Richard Bell, William J. McBride, Zachary Rodd

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The rate of codependency for alcohol and nicotine is extremely high. Numerous studies have indicated that there is a common genetic association for alcoholism and nicotine dependency. The current experiments examined whether selective breeding for high alcohol preference in rats may be associated with increased sensitivity of the posterior ventral tegmental area (pVTA) to the reinforcing properties of nicotine. In addition, nicotine can directly bind to the serotonin-3 (5-HT3) receptor, which has been shown to mediate the reinforcing properties of other drugs of abuse within the pVTA Wistar rats were assigned to groups that were allowed to self-infuse 0, 10, 50, 100, 200, 400 or 800 μM nicotine in two-lever (active and inactive) operant chambers. P rats were allowed to self-infuse 0, 1, 10, 50 or 100 μM nicotine. Co-infusion of 5-HT3 receptor antagonists with nicotine into the pVTA was also determined. P rats self-infused nicotine at lower concentrations than required to support self-administration in Wistar rats. In addition, P rats received more self-infusions of 50 and 100 μM nicotine than Wistar rats; including a 5HT3 receptor antagonist (LY-278,584 or zacopride) with nicotine reduced responding on the active lever. Overall, the data support an association between selective breeding for high alcohol preference and increased sensitivity of the pVTA to the reinforcing properties of nicotine. In addition, the data suggest that activation of 5HT3 receptors may be required to maintain the local reinforcing actions of nicotine within the pVTA. The current experiments examined whether selective breeding for high alcohol preference in P rats may be associated with increased sensitivity of the posterior ventral tegmental area to the reinforcing properties of nicotine. P rats self-infused nicotine at lower concentrations as well received more nicotine infusions than Wistar rats. In addition, a 5HT3 receptor antagonist with nicotine reduced responding on the active lever. The data supports an association between selective breeding for high alcohol preference and increased sensitivity of the pVTA to the reinforcing properties of nicotine.

Original languageEnglish
Pages (from-to)800-811
Number of pages12
JournalAddiction Biology
Volume19
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Nicotine
Alcohols
Ventral Tegmental Area
Wistar Rats
Receptors, Serotonin, 5-HT3
Selective Breeding
LY 278584
Serotonin 5-HT3 Receptor Antagonists
Self Administration
Street Drugs
Alcoholism

Keywords

  • Alcohol-preferring rats
  • intracranial self-administration
  • nicotine self-infusions
  • serotonin-3 receptors
  • ventral tegmental area

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Pharmacology
  • Medicine(all)

Cite this

Selective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine. / Hauser, Sheketha R.; Bracken, Amy L.; Deehan, Gerald A.; Toalston, Jamie E.; Ding, Zheng Ming; Truitt, William; Bell, Richard; McBride, William J.; Rodd, Zachary.

In: Addiction Biology, Vol. 19, No. 5, 2014, p. 800-811.

Research output: Contribution to journalArticle

Hauser, Sheketha R. ; Bracken, Amy L. ; Deehan, Gerald A. ; Toalston, Jamie E. ; Ding, Zheng Ming ; Truitt, William ; Bell, Richard ; McBride, William J. ; Rodd, Zachary. / Selective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine. In: Addiction Biology. 2014 ; Vol. 19, No. 5. pp. 800-811.
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