Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20

Ling Liu, Chunjin Ding, Wei Zeng, Josef G. Heuer, Jonathan W. Tetreault, Timothy W. Noblitt, Giao Hangoc, Scott Cooper, Kellie A. Brune, Ganesh Sharma, Niles Fox, Scott W. Rowlinson, Danise P. Rogers, Derrick R. Witcher, Peter K. Lambooy, Victor J. Wroblewski, James R. Miller, Hal E. Broxmeyer

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified.

Original languageEnglish (US)
Pages (from-to)3206-3209
Number of pages4
JournalBlood
Volume102
Issue number9
DOIs
StatePublished - Nov 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Liu, L., Ding, C., Zeng, W., Heuer, J. G., Tetreault, J. W., Noblitt, T. W., Hangoc, G., Cooper, S., Brune, K. A., Sharma, G., Fox, N., Rowlinson, S. W., Rogers, D. P., Witcher, D. R., Lambooy, P. K., Wroblewski, V. J., Miller, J. R., & Broxmeyer, H. E. (2003). Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Blood, 102(9), 3206-3209. https://doi.org/10.1182/blood-2003-05-1419