Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20

Ling Liu, Chunjin Ding, Wei Zeng, Josef G. Heuer, Jonathan W. Tetreault, Timothy W. Noblitt, Giao Hangoc, Scott Cooper, Kellie A. Brune, Ganesh Sharma, Niles Fox, Scott W. Rowlinson, Danise P. Rogers, Derrick R. Witcher, Peter K. Lambooy, Victor J. Wroblewski, James R. Miller, Hal Broxmeyer

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified.

Original languageEnglish (US)
Pages (from-to)3206-3209
Number of pages4
JournalBlood
Volume102
Issue number9
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

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Megakaryocyte Progenitor Cells
Granulocyte-Macrophage Progenitor Cells
Macrophages
Hematopoiesis
Transgenic Mice
Intercellular Signaling Peptides and Proteins
Stem Cells
Cell Count
interleukin 20
In Vitro Techniques
Cytokines

ASJC Scopus subject areas

  • Hematology

Cite this

Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. / Liu, Ling; Ding, Chunjin; Zeng, Wei; Heuer, Josef G.; Tetreault, Jonathan W.; Noblitt, Timothy W.; Hangoc, Giao; Cooper, Scott; Brune, Kellie A.; Sharma, Ganesh; Fox, Niles; Rowlinson, Scott W.; Rogers, Danise P.; Witcher, Derrick R.; Lambooy, Peter K.; Wroblewski, Victor J.; Miller, James R.; Broxmeyer, Hal.

In: Blood, Vol. 102, No. 9, 01.11.2003, p. 3206-3209.

Research output: Contribution to journalArticle

Liu, L, Ding, C, Zeng, W, Heuer, JG, Tetreault, JW, Noblitt, TW, Hangoc, G, Cooper, S, Brune, KA, Sharma, G, Fox, N, Rowlinson, SW, Rogers, DP, Witcher, DR, Lambooy, PK, Wroblewski, VJ, Miller, JR & Broxmeyer, H 2003, 'Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20', Blood, vol. 102, no. 9, pp. 3206-3209. https://doi.org/10.1182/blood-2003-05-1419
Liu L, Ding C, Zeng W, Heuer JG, Tetreault JW, Noblitt TW et al. Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Blood. 2003 Nov 1;102(9):3206-3209. https://doi.org/10.1182/blood-2003-05-1419
Liu, Ling ; Ding, Chunjin ; Zeng, Wei ; Heuer, Josef G. ; Tetreault, Jonathan W. ; Noblitt, Timothy W. ; Hangoc, Giao ; Cooper, Scott ; Brune, Kellie A. ; Sharma, Ganesh ; Fox, Niles ; Rowlinson, Scott W. ; Rogers, Danise P. ; Witcher, Derrick R. ; Lambooy, Peter K. ; Wroblewski, Victor J. ; Miller, James R. ; Broxmeyer, Hal. / Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. In: Blood. 2003 ; Vol. 102, No. 9. pp. 3206-3209.
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AU - Cooper, Scott

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AU - Fox, Niles

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