Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids

Dawei Ma, Yongwen Jiang, Fangping Chen, Li Kun Gong, Ke Ding, Yong Xu, Renxiao Wang, Aihua Ge, Jin Ren, Jingya Li, Jia Li, Qizhuang Ye

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of γ-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC50 values between 0.20 and 1.51 μM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalJournal of Medicinal Chemistry
Volume49
Issue number2
DOIs
StatePublished - Jan 26 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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