Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids

Dawei Ma, Yongwen Jiang, Fangping Chen, Li Kun Gong, Ke Ding, Yong Xu, Renxiao Wang, Aihua Ge, Jin Ren, Jingya Li, Jia Li, Qizhuang Ye

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of γ-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC50 values between 0.20 and 1.51 μM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalJournal of Medicinal Chemistry
Volume49
Issue number2
DOIs
StatePublished - Jan 26 2006
Externally publishedYes

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Keto Acids
Emphysema
Carboxylic Acids
Matrix Metalloproteinases
Isoenzymes
Matrix Metalloproteinase 2
Mesocricetus
Matrix Metalloproteinase 9
Inhibitory Concentration 50

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids. / Ma, Dawei; Jiang, Yongwen; Chen, Fangping; Gong, Li Kun; Ding, Ke; Xu, Yong; Wang, Renxiao; Ge, Aihua; Ren, Jin; Li, Jingya; Li, Jia; Ye, Qizhuang.

In: Journal of Medicinal Chemistry, Vol. 49, No. 2, 26.01.2006, p. 456-458.

Research output: Contribution to journalArticle

Ma, Dawei ; Jiang, Yongwen ; Chen, Fangping ; Gong, Li Kun ; Ding, Ke ; Xu, Yong ; Wang, Renxiao ; Ge, Aihua ; Ren, Jin ; Li, Jingya ; Li, Jia ; Ye, Qizhuang. / Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 2. pp. 456-458.
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AU - Chen, Fangping

AU - Gong, Li Kun

AU - Ding, Ke

AU - Xu, Yong

AU - Wang, Renxiao

AU - Ge, Aihua

AU - Ren, Jin

AU - Li, Jingya

AU - Li, Jia

AU - Ye, Qizhuang

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