Selective phosphorylation of human DNA methyltransferase by protein kinase C

Anna De Paoli-Roach, Peter Roach, Keith E. Zucker, Steven S. Smith

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalFEBS Letters
Volume197
Issue number1-2
DOIs
StatePublished - Mar 3 1986

Fingerprint

Phosphorylation
Methyltransferases
DNA Methylation
Protein Kinase C
Inheritance Patterns
DNA
Phorbol Esters
Tumors
Substrates
Enzymes
Neoplasms

Keywords

  • DNA methylation (Human placenta) DNA methyltransferase Phorbol ester Protein kinase C Protein phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Selective phosphorylation of human DNA methyltransferase by protein kinase C. / De Paoli-Roach, Anna; Roach, Peter; Zucker, Keith E.; Smith, Steven S.

In: FEBS Letters, Vol. 197, No. 1-2, 03.03.1986, p. 149-153.

Research output: Contribution to journalArticle

De Paoli-Roach, Anna ; Roach, Peter ; Zucker, Keith E. ; Smith, Steven S. / Selective phosphorylation of human DNA methyltransferase by protein kinase C. In: FEBS Letters. 1986 ; Vol. 197, No. 1-2. pp. 149-153.
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