Selective phosphorylation of human DNA methyltransferase by protein kinase C

Anna DePaoli-Roach, Peter J. Roach, Keith E. Zucker, Steven S. Smith

Research output: Contribution to journalArticle

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Abstract

Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalFEBS Letters
Volume197
Issue number1-2
DOIs
StatePublished - Mar 3 1986

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Keywords

  • DNA methylation (Human placenta) DNA methyltransferase Phorbol ester Protein kinase C Protein phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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