Seleninate in place of phosphate

Irreversible inhibition of protein tyrosine phosphatases

Mohannad Abdo, Sijiu Liu, Bo Zhou, Chad D. Walls, Li Wu, Spencer Knapp, Zhong-Yin Zhang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.

Original languageEnglish
Pages (from-to)13196-13197
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number40
DOIs
StatePublished - Oct 8 2008

Fingerprint

Enzyme inhibition
Protein Tyrosine Phosphatases
Phosphatases
Cysteine
Catalytic Domain
Phosphates
Proteins
Kinetics
Acids
seleninic acid

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Seleninate in place of phosphate : Irreversible inhibition of protein tyrosine phosphatases. / Abdo, Mohannad; Liu, Sijiu; Zhou, Bo; Walls, Chad D.; Wu, Li; Knapp, Spencer; Zhang, Zhong-Yin.

In: Journal of the American Chemical Society, Vol. 130, No. 40, 08.10.2008, p. 13196-13197.

Research output: Contribution to journalArticle

Abdo, Mohannad ; Liu, Sijiu ; Zhou, Bo ; Walls, Chad D. ; Wu, Li ; Knapp, Spencer ; Zhang, Zhong-Yin. / Seleninate in place of phosphate : Irreversible inhibition of protein tyrosine phosphatases. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 40. pp. 13196-13197.
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