Seleninate in place of phosphate: Irreversible inhibition of protein tyrosine phosphatases

Mohannad Abdo, Sijiu Liu, Bo Zhou, Chad D. Walls, Li Wu, Spencer Knapp, Zhong Yin Zhang

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.

Original languageEnglish (US)
Pages (from-to)13196-13197
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number40
DOIs
StatePublished - Oct 8 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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