Selenium and cardiovascular disease: Epidemiological evidence of a possible u-shaped relationship

Xi Zhang, Xinli Li, Weili Zhang, Yiqing Song

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Selenium is an essential mineral that plays a crucial role in the regulation of cardiovascular system. The relation between selenium and cardiovascular disease (CVD) has been studied extensively over the last decades. In human prospective observational studies, there seems a U-shaped association between baseline selenium status and CVD risk, indicating possible adverse cardiometabolic effects of very low and high selenium levels. A few randomized controlled trials (RCTs) have evaluated the effects of selenium on CVD but showed no obvious benefits or risks. However, different population selenium status, selenium formulae, dosage, and intervention durations as well as trial quality may have contributed to between-trial heterogeneity, which largely prevents us from drawing causal conclusions. This chapter focuses on current evidence from prospective data, which helps to gain a more comprehensive insight into the selenium-CVD relationship and provide reasonable explanations of the discrepancies between results from human observational and interventional studies.

Original languageEnglish (US)
Title of host publicationMolecular and Integrative Toxicology
PublisherSpringer Science+Business Media B.V.
Pages303-316
Number of pages14
DOIs
StatePublished - 2018

Publication series

NameMolecular and Integrative Toxicology
ISSN (Print)2168-4219
ISSN (Electronic)2168-4235

Keywords

  • Cardiovascular disease (CVD)
  • Glutathione peroxidase (GPX)
  • Meta-analysis
  • Observational studies
  • Randomized controlled trials (RCTs)
  • Selenium
  • Selenoproteins
  • Supplementation
  • Systematic review

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Drug Discovery
  • Toxicology

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  • Cite this

    Zhang, X., Li, X., Zhang, W., & Song, Y. (2018). Selenium and cardiovascular disease: Epidemiological evidence of a possible u-shaped relationship. In Molecular and Integrative Toxicology (pp. 303-316). (Molecular and Integrative Toxicology). Springer Science+Business Media B.V.. https://doi.org/10.1007/978-3-319-95390-8_16