Selenium level and cognitive function in rural elderly Chinese

Sujuan Gao, Yinlong Jin, Kathleen S. Hall, Chaoke Liang, Frederick W. Unverzagt, Rongdi Ji, Jill R. Murrell, Jingxiang Cao, Jianzhao Shen, Feng Ma, Janetta Matesan, Bo Ying, Yibin Cheng, Jianchao Bian, Ping Li, Hugh C. Hendrie

Research output: Contribution to journalArticle

100 Scopus citations


Selenium is a trace element associated with antioxidant activity and is considered to be a protective agent against free radicals through enhanced enzyme activity. Studies on selenium and cognitive function or Alzheimer's disease have yielded inconsistent results. A cross-sectional survey of 2,000 rural Chinese aged 65 years or older from two provinces in the People's Republic of China was conducted from December 2003 to May 2005 by use of the Community Screening Instrument for Dementia, the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Learning Test, the Indiana University Story Recall Test, the Animal Fluency Test, and the Indiana University Token Test. Over 70% of the study participants have lived in the same village since birth. Nail samples were collected and analyzed for selenium contents. Analysis-of-covariance models were used to estimate the association between quintile selenium levels measured in nail samples and cognitive test scores, with adjustment for other covariates. Lower selenium levels measured in nail samples were significantly associated with lower cognitive scores (p < 0.0087 for all tests) except the Animal Fluency Test (p = 0.4378). A dose-response effect of selenium quintiles was also seen for those significant associations. Results in this geographically stable cohort support the hypothesis that a lifelong low selenium level is associated with lower cognitive function.

Original languageEnglish (US)
Pages (from-to)955-965
Number of pages11
JournalAmerican journal of epidemiology
Issue number8
StatePublished - Apr 1 2007


  • Aged
  • Asian continental ancestry group
  • Cognition
  • Selenium

ASJC Scopus subject areas

  • Epidemiology

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    Gao, S., Jin, Y., Hall, K. S., Liang, C., Unverzagt, F. W., Ji, R., Murrell, J. R., Cao, J., Shen, J., Ma, F., Matesan, J., Ying, B., Cheng, Y., Bian, J., Li, P., & Hendrie, H. C. (2007). Selenium level and cognitive function in rural elderly Chinese. American journal of epidemiology, 165(8), 955-965.