Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions

Satoshi Ikemoto, James M. Murphy, William J. McBride

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

This study used an intracerebral self-administration paradigm in rats to determine if blockade of GABA(A) receptors in the ventral tegmental area (VTA) has a reinforcing effect. Rats quickly learned to self-infuse a picrotoxin solution into the anterior VTA; rats discriminated the lever that produced picrotoxin infusions from the lever without consequences; and when the response requirement was increased, rats increased response levels for picrotoxin infusion. The reinforcing effect of picrotoxin was site-specific: Anterior VTA regions supported vigorous self-infusion, but not the posterior VTA, substantia nigra, or lateral hypothalamus. Muscimol, a GABA(A) agonist, disrupted picrotoxin self-infusion, but bicuculline, a GABA(A) antagonist, was self-infused into the VTA. The results suggest that blockade of GABA(A) receptors in the anterior VTA is reinforcing and that functional organization of the GABA systems within the VTA is heterogeneous.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalBehavioral Neuroscience
Volume111
Issue number2
DOIs
StatePublished - Apr 1997

Fingerprint

GABA-A Receptor Antagonists
Ventral Tegmental Area
Picrotoxin
GABA-A Receptors
Lateral Hypothalamic Area
GABA-A Receptor Agonists
Muscimol
Self Administration
Bicuculline
Substantia Nigra
gamma-Aminobutyric Acid

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions. / Ikemoto, Satoshi; Murphy, James M.; McBride, William J.

In: Behavioral Neuroscience, Vol. 111, No. 2, 04.1997, p. 369-380.

Research output: Contribution to journalArticle

Ikemoto, Satoshi ; Murphy, James M. ; McBride, William J. / Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions. In: Behavioral Neuroscience. 1997 ; Vol. 111, No. 2. pp. 369-380.
@article{85889bea0e474295adcbef6d92e8a732,
title = "Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions",
abstract = "This study used an intracerebral self-administration paradigm in rats to determine if blockade of GABA(A) receptors in the ventral tegmental area (VTA) has a reinforcing effect. Rats quickly learned to self-infuse a picrotoxin solution into the anterior VTA; rats discriminated the lever that produced picrotoxin infusions from the lever without consequences; and when the response requirement was increased, rats increased response levels for picrotoxin infusion. The reinforcing effect of picrotoxin was site-specific: Anterior VTA regions supported vigorous self-infusion, but not the posterior VTA, substantia nigra, or lateral hypothalamus. Muscimol, a GABA(A) agonist, disrupted picrotoxin self-infusion, but bicuculline, a GABA(A) antagonist, was self-infused into the VTA. The results suggest that blockade of GABA(A) receptors in the anterior VTA is reinforcing and that functional organization of the GABA systems within the VTA is heterogeneous.",
author = "Satoshi Ikemoto and Murphy, {James M.} and McBride, {William J.}",
year = "1997",
month = "4",
doi = "10.1037/0735-7044.111.2.369",
language = "English",
volume = "111",
pages = "369--380",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "2",

}

TY - JOUR

T1 - Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions

AU - Ikemoto, Satoshi

AU - Murphy, James M.

AU - McBride, William J.

PY - 1997/4

Y1 - 1997/4

N2 - This study used an intracerebral self-administration paradigm in rats to determine if blockade of GABA(A) receptors in the ventral tegmental area (VTA) has a reinforcing effect. Rats quickly learned to self-infuse a picrotoxin solution into the anterior VTA; rats discriminated the lever that produced picrotoxin infusions from the lever without consequences; and when the response requirement was increased, rats increased response levels for picrotoxin infusion. The reinforcing effect of picrotoxin was site-specific: Anterior VTA regions supported vigorous self-infusion, but not the posterior VTA, substantia nigra, or lateral hypothalamus. Muscimol, a GABA(A) agonist, disrupted picrotoxin self-infusion, but bicuculline, a GABA(A) antagonist, was self-infused into the VTA. The results suggest that blockade of GABA(A) receptors in the anterior VTA is reinforcing and that functional organization of the GABA systems within the VTA is heterogeneous.

AB - This study used an intracerebral self-administration paradigm in rats to determine if blockade of GABA(A) receptors in the ventral tegmental area (VTA) has a reinforcing effect. Rats quickly learned to self-infuse a picrotoxin solution into the anterior VTA; rats discriminated the lever that produced picrotoxin infusions from the lever without consequences; and when the response requirement was increased, rats increased response levels for picrotoxin infusion. The reinforcing effect of picrotoxin was site-specific: Anterior VTA regions supported vigorous self-infusion, but not the posterior VTA, substantia nigra, or lateral hypothalamus. Muscimol, a GABA(A) agonist, disrupted picrotoxin self-infusion, but bicuculline, a GABA(A) antagonist, was self-infused into the VTA. The results suggest that blockade of GABA(A) receptors in the anterior VTA is reinforcing and that functional organization of the GABA systems within the VTA is heterogeneous.

UR - http://www.scopus.com/inward/record.url?scp=0030973582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030973582&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.111.2.369

DO - 10.1037/0735-7044.111.2.369

M3 - Article

VL - 111

SP - 369

EP - 380

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 2

ER -