Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.

Original languageEnglish (US)
Article number1918
Pages (from-to)1080-1089
Number of pages10
JournalAlzheimer's and Dementia
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • ADNI
  • Alzheimer's disease
  • Biomarkers
  • Daily functioning
  • Dementia
  • Everyday function
  • Informant-report
  • Instrumental activities of daily living
  • Mild cognitive impairment (MCI)
  • Self-report

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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