Self-reactive γδ T cells are eliminated in the thymus

Alexander Dent, Louis A. Matis, Farideh Hooshmand, Suzanne M. Widacki, Jeffrey A. Bluestone, Stephen M. Hedrick

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

The genes encoding a γδ T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the Tla locus have been inserted into the mouse germ line. In mice that do not express the Tla-encoded determinant, transgenic γδ T cells are a functional component of the CD4-CD8- 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the Tla-encoded determinant, there are no transgenic γδ T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic γδ T-cell receptor.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalNature
Volume343
Issue number6260
StatePublished - Feb 22 1990
Externally publishedYes

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Thymus Gland
T-Cell Antigen Receptor
T-Lymphocytes
Thymocytes
Major Histocompatibility Complex
Germ Cells
Genes

ASJC Scopus subject areas

  • General

Cite this

Dent, A., Matis, L. A., Hooshmand, F., Widacki, S. M., Bluestone, J. A., & Hedrick, S. M. (1990). Self-reactive γδ T cells are eliminated in the thymus. Nature, 343(6260), 714-719.

Self-reactive γδ T cells are eliminated in the thymus. / Dent, Alexander; Matis, Louis A.; Hooshmand, Farideh; Widacki, Suzanne M.; Bluestone, Jeffrey A.; Hedrick, Stephen M.

In: Nature, Vol. 343, No. 6260, 22.02.1990, p. 714-719.

Research output: Contribution to journalArticle

Dent, A, Matis, LA, Hooshmand, F, Widacki, SM, Bluestone, JA & Hedrick, SM 1990, 'Self-reactive γδ T cells are eliminated in the thymus', Nature, vol. 343, no. 6260, pp. 714-719.
Dent A, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM. Self-reactive γδ T cells are eliminated in the thymus. Nature. 1990 Feb 22;343(6260):714-719.
Dent, Alexander ; Matis, Louis A. ; Hooshmand, Farideh ; Widacki, Suzanne M. ; Bluestone, Jeffrey A. ; Hedrick, Stephen M. / Self-reactive γδ T cells are eliminated in the thymus. In: Nature. 1990 ; Vol. 343, No. 6260. pp. 714-719.
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