Self-reactive γδ T cells are eliminated in the thymus

Alexander L. Dent, Louis A. Matis, Farideh Hooshmand, Suzanne M. Widacki, Jeffrey A. Bluestone, Stephen M. Hedrick

Research output: Contribution to journalArticle

189 Scopus citations


The genes encoding a γδ T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the Tla locus have been inserted into the mouse germ line. In mice that do not express the Tla-encoded determinant, transgenic γδ T cells are a functional component of the CD4∼CD8∼ 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the Tla-encoded determinant, there are no transgenic γδ T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic γδ T-cell receptor.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
Issue number6260
StatePublished - Jan 1 1990
Externally publishedYes

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    Dent, A. L., Matis, L. A., Hooshmand, F., Widacki, S. M., Bluestone, J. A., & Hedrick, S. M. (1990). Self-reactive γδ T cells are eliminated in the thymus. Nature, 343(6260), 714-719.