Semaphorins at the interface of development and cancer

E. Flannery, M. Duman-Scheel

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Semaphorins (Semas), a family of evolutionarily conserved secreted and transmembrane proteins, were initially identified as axon guidance regulators and have since been implicated in the development of a number of other tissues. Sema signaling also regulates a variety of processes that are linked to cancer (i.e. metastasis, cell migration, cell growth). The mechanisms by which Sema signaling regulates axonogenesis and tumorigenesis are strikingly similar, making advances in either field applicable to the alternate discipline. Here, recent advances in understanding the roles of Semas in development and cancer, as well as the therapeutic potential for targeting this signaling pathway in human cancers, are reviewed.

Original languageEnglish (US)
Pages (from-to)611-619
Number of pages9
JournalCurrent Drug Targets
Volume10
Issue number7
DOIs
StatePublished - Nov 26 2009

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Keywords

  • Axon guidance
  • Cancer
  • Development
  • Plexin
  • Semaphorin

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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