Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle

Rodolfo Montironi, Antonio Lopez-Beltran, Liang Cheng, Andrea B. Galosi, Francesco Montorsi, Marina Scarpelli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than the surrounding normal ducts with obliteration of the acinar lumen. At high magnification, there were varying degrees of cell stratification. Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells. The case shows morphologic and immunohistochemical features similar to those of basal cell hyperplasia of the prostate and is different from the early neoplastic epithelial changes of the SV in the transgenic adenocarcinoma mouse prostate model (ie, SV intraepithelial neoplasia). To the best of our knowledge, there are no previous reports of such a change in a human SV. The clinical significance of this lesion is not known and is overshadowed by the presence of prostate cancer.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalEuropean Urology
Volume66
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Seminal Vesicles
Hyperplasia
Prostate
Neoplasms
Adenocarcinoma
Keratin-6
Keratin-5
Prostate-Specific Antigen
Prostatectomy
Acid Phosphatase
Transgenic Mice
Prostatic Neoplasms
Carrier Proteins

Keywords

  • Adenocarcinoma
  • Basal cell proliferation
  • Intraepithelial proliferation
  • Preneoplastic change
  • Seminal vesicle
  • Seminal vesicle intraepithelial neoplasia

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle. / Montironi, Rodolfo; Lopez-Beltran, Antonio; Cheng, Liang; Galosi, Andrea B.; Montorsi, Francesco; Scarpelli, Marina.

In: European Urology, Vol. 66, No. 4, 2014, p. 623-627.

Research output: Contribution to journalArticle

Montironi, R, Lopez-Beltran, A, Cheng, L, Galosi, AB, Montorsi, F & Scarpelli, M 2014, 'Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle', European Urology, vol. 66, no. 4, pp. 623-627. https://doi.org/10.1016/j.eururo.2014.02.054
Montironi, Rodolfo ; Lopez-Beltran, Antonio ; Cheng, Liang ; Galosi, Andrea B. ; Montorsi, Francesco ; Scarpelli, Marina. / Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle. In: European Urology. 2014 ; Vol. 66, No. 4. pp. 623-627.
@article{058a5959ea5045d19492ce8bd31c38db,
title = "Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle",
abstract = "In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than the surrounding normal ducts with obliteration of the acinar lumen. At high magnification, there were varying degrees of cell stratification. Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells. The case shows morphologic and immunohistochemical features similar to those of basal cell hyperplasia of the prostate and is different from the early neoplastic epithelial changes of the SV in the transgenic adenocarcinoma mouse prostate model (ie, SV intraepithelial neoplasia). To the best of our knowledge, there are no previous reports of such a change in a human SV. The clinical significance of this lesion is not known and is overshadowed by the presence of prostate cancer.",
keywords = "Adenocarcinoma, Basal cell proliferation, Intraepithelial proliferation, Preneoplastic change, Seminal vesicle, Seminal vesicle intraepithelial neoplasia",
author = "Rodolfo Montironi and Antonio Lopez-Beltran and Liang Cheng and Galosi, {Andrea B.} and Francesco Montorsi and Marina Scarpelli",
year = "2014",
doi = "10.1016/j.eururo.2014.02.054",
language = "English (US)",
volume = "66",
pages = "623--627",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle

AU - Montironi, Rodolfo

AU - Lopez-Beltran, Antonio

AU - Cheng, Liang

AU - Galosi, Andrea B.

AU - Montorsi, Francesco

AU - Scarpelli, Marina

PY - 2014

Y1 - 2014

N2 - In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than the surrounding normal ducts with obliteration of the acinar lumen. At high magnification, there were varying degrees of cell stratification. Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells. The case shows morphologic and immunohistochemical features similar to those of basal cell hyperplasia of the prostate and is different from the early neoplastic epithelial changes of the SV in the transgenic adenocarcinoma mouse prostate model (ie, SV intraepithelial neoplasia). To the best of our knowledge, there are no previous reports of such a change in a human SV. The clinical significance of this lesion is not known and is overshadowed by the presence of prostate cancer.

AB - In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than the surrounding normal ducts with obliteration of the acinar lumen. At high magnification, there were varying degrees of cell stratification. Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells. The case shows morphologic and immunohistochemical features similar to those of basal cell hyperplasia of the prostate and is different from the early neoplastic epithelial changes of the SV in the transgenic adenocarcinoma mouse prostate model (ie, SV intraepithelial neoplasia). To the best of our knowledge, there are no previous reports of such a change in a human SV. The clinical significance of this lesion is not known and is overshadowed by the presence of prostate cancer.

KW - Adenocarcinoma

KW - Basal cell proliferation

KW - Intraepithelial proliferation

KW - Preneoplastic change

KW - Seminal vesicle

KW - Seminal vesicle intraepithelial neoplasia

UR - http://www.scopus.com/inward/record.url?scp=84908357059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908357059&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2014.02.054

DO - 10.1016/j.eururo.2014.02.054

M3 - Article

C2 - 24631410

AN - SCOPUS:84908357059

VL - 66

SP - 623

EP - 627

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 4

ER -