Seminoma with conspicuous signet ring cells: A rare, previously uncharacterized morphologic variant

Thomas M. Ulbright, Robert H. Young

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure. The signet ring cells occurred in a multifocal fashion in areas of otherwise typical seminoma and comprised approximately 70% and 10%, respectively, of the tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed the nuclei to a peripheral crescent. In 1 case, the vacuoles contained numerous refractile, nonpolarizable globular deposits that were shown to be glycogen on the basis of periodic acid-Schiff stain positivity that was abolished by pretreatment with diastase; in the second case, they mostly appeared "empty" and lacked periodic acid-Schiff positivity. The signet ring cells were mucicarmine, cytokeratin (AE1/3) and α-fetoprotein negative, but positive for OCT3/4 and CD117, the latter 2 being expected for seminoma cells. A review of 30 randomly selected seminomas identified very rare, inconspicuous signet ring cells in 43%. The presence of prominent signet ring cells in seminoma may cause confusion as it has not been described previously in detail, and a variety of neoplasms, particularly metastasis, may be considered. The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm.

Original languageEnglish (US)
Pages (from-to)1175-1181
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2008

Fingerprint

Seminoma
Periodic Acid
Vacuoles
Keratin-3
Fetal Proteins
Germ Cell and Embryonal Neoplasms
Testicular Neoplasms
Amylases
Glycogen
Neoplasms
Coloring Agents
Neoplasm Metastasis

Keywords

  • Seminoma
  • Signet ring cells
  • Testicular neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Seminoma with conspicuous signet ring cells : A rare, previously uncharacterized morphologic variant. / Ulbright, Thomas M.; Young, Robert H.

In: American Journal of Surgical Pathology, Vol. 32, No. 8, 01.08.2008, p. 1175-1181.

Research output: Contribution to journalArticle

@article{57ece92d453849a899bec913afc68733,
title = "Seminoma with conspicuous signet ring cells: A rare, previously uncharacterized morphologic variant",
abstract = "We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure. The signet ring cells occurred in a multifocal fashion in areas of otherwise typical seminoma and comprised approximately 70{\%} and 10{\%}, respectively, of the tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed the nuclei to a peripheral crescent. In 1 case, the vacuoles contained numerous refractile, nonpolarizable globular deposits that were shown to be glycogen on the basis of periodic acid-Schiff stain positivity that was abolished by pretreatment with diastase; in the second case, they mostly appeared {"}empty{"} and lacked periodic acid-Schiff positivity. The signet ring cells were mucicarmine, cytokeratin (AE1/3) and α-fetoprotein negative, but positive for OCT3/4 and CD117, the latter 2 being expected for seminoma cells. A review of 30 randomly selected seminomas identified very rare, inconspicuous signet ring cells in 43{\%}. The presence of prominent signet ring cells in seminoma may cause confusion as it has not been described previously in detail, and a variety of neoplasms, particularly metastasis, may be considered. The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm.",
keywords = "Seminoma, Signet ring cells, Testicular neoplasms",
author = "Ulbright, {Thomas M.} and Young, {Robert H.}",
year = "2008",
month = "8",
day = "1",
doi = "10.1097/PAS.0b013e31816597b0",
language = "English (US)",
volume = "32",
pages = "1175--1181",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Seminoma with conspicuous signet ring cells

T2 - A rare, previously uncharacterized morphologic variant

AU - Ulbright, Thomas M.

AU - Young, Robert H.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure. The signet ring cells occurred in a multifocal fashion in areas of otherwise typical seminoma and comprised approximately 70% and 10%, respectively, of the tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed the nuclei to a peripheral crescent. In 1 case, the vacuoles contained numerous refractile, nonpolarizable globular deposits that were shown to be glycogen on the basis of periodic acid-Schiff stain positivity that was abolished by pretreatment with diastase; in the second case, they mostly appeared "empty" and lacked periodic acid-Schiff positivity. The signet ring cells were mucicarmine, cytokeratin (AE1/3) and α-fetoprotein negative, but positive for OCT3/4 and CD117, the latter 2 being expected for seminoma cells. A review of 30 randomly selected seminomas identified very rare, inconspicuous signet ring cells in 43%. The presence of prominent signet ring cells in seminoma may cause confusion as it has not been described previously in detail, and a variety of neoplasms, particularly metastasis, may be considered. The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm.

AB - We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure. The signet ring cells occurred in a multifocal fashion in areas of otherwise typical seminoma and comprised approximately 70% and 10%, respectively, of the tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed the nuclei to a peripheral crescent. In 1 case, the vacuoles contained numerous refractile, nonpolarizable globular deposits that were shown to be glycogen on the basis of periodic acid-Schiff stain positivity that was abolished by pretreatment with diastase; in the second case, they mostly appeared "empty" and lacked periodic acid-Schiff positivity. The signet ring cells were mucicarmine, cytokeratin (AE1/3) and α-fetoprotein negative, but positive for OCT3/4 and CD117, the latter 2 being expected for seminoma cells. A review of 30 randomly selected seminomas identified very rare, inconspicuous signet ring cells in 43%. The presence of prominent signet ring cells in seminoma may cause confusion as it has not been described previously in detail, and a variety of neoplasms, particularly metastasis, may be considered. The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm.

KW - Seminoma

KW - Signet ring cells

KW - Testicular neoplasms

UR - http://www.scopus.com/inward/record.url?scp=49249123751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49249123751&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e31816597b0

DO - 10.1097/PAS.0b013e31816597b0

M3 - Article

C2 - 18580681

AN - SCOPUS:49249123751

VL - 32

SP - 1175

EP - 1181

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 8

ER -