Sensitive Cytologic Criteria for the Identification of Follicular Variant of Papillary Thyroid Carcinoma in Fine-Needle Aspiration Biopsy

Howard Wu, Jennifer N. Jones, Dana Marie Grzybicki, Tarik M. Elsheikh

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The cytologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) can be extremely challenging and may be associated with false negative diagnoses. The purpose of this study was to determine the minimal cytologic criteria needed to identify FVPTC. We examined sixty-nine fine-needle aspiration (FNA) cases, processed with Diff-Quik and Papanicolaou stains, that were either diagnostic or suspicious of FVPTC. All cases had histologic confirmation. These cases included 29 FVPTC, 18 classic papillary thyroid carcinoma (PTC), 17 follicular neoplasm (6 adenomas, 10 carcinomas, 1 neoplasm NOS), 2 lymphocytic thyroiditis and 3 nodular goiter. Seven of the most commonly cited cytomorphologic features, including flat syncytial sheets, nuclear enlargement, fine chromatin, nuclear grooves, nuclear pseudoinclusions, and amount of colloid and cytoplasm, were evaluated. A diffuse distribution of fine chromatin, nuclear grooves, and colloid was seen more often in FVPTC than in follicular neoplasm (p

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalDiagnostic Cytopathology
Volume29
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

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Fine Needle Biopsy
Colloids
Chromatin
Nodular Goiter
Autoimmune Thyroiditis
Neoplasms
Adenoma
Papillary Thyroid cancer
Cytoplasm
Carcinoma

Keywords

  • Fine needle aspiration
  • Follicular variant of papillary thyroid carcinoma
  • Thyroid cytology

ASJC Scopus subject areas

  • Anatomy

Cite this

Sensitive Cytologic Criteria for the Identification of Follicular Variant of Papillary Thyroid Carcinoma in Fine-Needle Aspiration Biopsy. / Wu, Howard; Jones, Jennifer N.; Grzybicki, Dana Marie; Elsheikh, Tarik M.

In: Diagnostic Cytopathology, Vol. 29, No. 5, 11.2003, p. 262-266.

Research output: Contribution to journalArticle

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