Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures

Ann E. Kosobud; John C. Crabbe

doi:10.1016/0006-8993(93)91235-K

Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures

Ann E. Kosobud, John C. Crabbe

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.

Original language	English (US)
Pages (from-to)	176-179
Number of pages	4
Journal	Brain research
Volume	610
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)91235-K
State	Published - Apr 30 1993
Externally published	Yes

Keywords

Behavior genetics
Convulsion
Ethanol
Ethanol withdrawal
N-Methyl-d-aspartic acid
Pharmacogenetics
Selected mouse line

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(93)91235-K

Fingerprint Dive into the research topics of 'Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures'. Together they form a unique fingerprint.

Cite this

Kosobud, A. E., & Crabbe, J. C. (1993). Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures. Brain research, 610(1), 176-179. https://doi.org/10.1016/0006-8993(93)91235-K

@article{4e4cb54981f44a3aac6d14b208c79493,

title = "Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures",

abstract = "Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.",

keywords = "Behavior genetics, Convulsion, Ethanol, Ethanol withdrawal, N-Methyl-d-aspartic acid, Pharmacogenetics, Selected mouse line",

author = "Kosobud, {Ann E.} and Crabbe, {John C.}",

year = "1993",

month = apr,

day = "30",

doi = "10.1016/0006-8993(93)91235-K",

language = "English (US)",

volume = "610",

pages = "176--179",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures

AU - Kosobud, Ann E.

AU - Crabbe, John C.

PY - 1993/4/30

Y1 - 1993/4/30

N2 - Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.

AB - Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.

KW - Behavior genetics

KW - Convulsion

KW - Ethanol

KW - Ethanol withdrawal

KW - N-Methyl-d-aspartic acid

KW - Pharmacogenetics

KW - Selected mouse line

UR - http://www.scopus.com/inward/record.url?scp=0027297952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027297952&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(93)91235-K

DO - 10.1016/0006-8993(93)91235-K

M3 - Article

C2 - 8518927

AN - SCOPUS:0027297952

VL - 610

SP - 176

EP - 179

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -