Abstract
Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 176-179 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 610 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 30 1993 |
| Externally published | Yes |
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Keywords
- Behavior genetics
- Convulsion
- Ethanol
- Ethanol withdrawal
- N-Methyl-d-aspartic acid
- Pharmacogenetics
- Selected mouse line
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures. / Kosobud, Ann; Crabbe, John C.
In: Brain Research, Vol. 610, No. 1, 30.04.1993, p. 176-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures
AU - Kosobud, Ann
AU - Crabbe, John C.
PY - 1993/4/30
Y1 - 1993/4/30
N2 - Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.
AB - Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.
KW - Behavior genetics
KW - Convulsion
KW - Ethanol
KW - Ethanol withdrawal
KW - N-Methyl-d-aspartic acid
KW - Pharmacogenetics
KW - Selected mouse line
UR - http://www.scopus.com/inward/record.url?scp=0027297952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027297952&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(93)91235-K
DO - 10.1016/0006-8993(93)91235-K
M3 - Article
C2 - 8518927
AN - SCOPUS:0027297952
VL - 610
SP - 176
EP - 179
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -