Sensitivity to N-methyl-d-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures

Ann E. Kosobud, John C. Crabbe

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Mice genetically selected to be resistant (withdrawal-seizure resistant, WSR) or prone (withdrawal-seizure prone, WSP) to handling-induced convulsions during ethanol withdrawal were tested for sensitivity to convulsions induced by timed intravenous (i.v.) infusion of N-methyl- d-aspartic acid (NMDA). WSR mice displayed convulsions at infused doses of NMDA that averaged 20% lower than WSP mice. This result was present in both genetically independent replicates of the WSR and WSP mice and provides strong evidence for an involvelment of the NMDA system in the difference in withdrawal seizures present in these lines.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalBrain research
Volume610
Issue number1
DOIs
StatePublished - Apr 30 1993
Externally publishedYes

Keywords

  • Behavior genetics
  • Convulsion
  • Ethanol
  • Ethanol withdrawal
  • N-Methyl-d-aspartic acid
  • Pharmacogenetics
  • Selected mouse line

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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