Sentinel lymph node biopsy in thin melanoma patients.

Dan D. Hershko, Bruce Robb, Andrew M. Lowy, Syed A. Ahmad, G. H. Ramadas, Debbie A. Soldano, Jeffrey J. Sussman

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

BACKGROUND: We sought to determine the incidence of positive sentinel lymph nodes in thin melanoma (or= III and thicker lesions (mean 0.77 mm vs. 0.47 mm), but were not different in regards to age, sex, or lesion location. Eight percent and 58% of sentinel nodes were positive by routine histology and RT-PCR, respectively. Among mapped patients, younger age was the only significant prognostic factor for node positivity. With a median follow-up of 18 months among all patients, one regional recurrence (at 2 years) has been identified. CONCLUSIONS: Given the low morbidity of sentinel lymph node biopsy, this procedure should be discussed with selected thin melanoma patients to detect microscopic disease, however PCR positivity by our methods is too commonly seen to be clinically significant in thin melanoma patients and requires additional study. (c) 2006 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalJournal of Surgical Oncology
Volume93
Issue number4
DOIs
StatePublished - Mar 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Hershko, D. D., Robb, B., Lowy, A. M., Ahmad, S. A., Ramadas, G. H., Soldano, D. A., & Sussman, J. J. (2006). Sentinel lymph node biopsy in thin melanoma patients. Journal of Surgical Oncology, 93(4), 279-285. https://doi.org/10.1002/jso.20415