Septal TRH in alcohol-naive P and NP rats and following alcohol challenge

Sandra Morzorati, Michael J. Kubek

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Regional brain content of TRH was evaluated in selectively bred alcohol-preferring (P) and -nonpreferring (NP) rats before, during, and upon awakening from ethanol sedation. TRH content was significantly lower in both the medial and lateral septum of alcohol-naive P rats compared with alcohol-naive NP rats. Following a sedating dose of ethanol, P rats righted themselves sooner than NP rats. TRH content in the medial septum of P and NP rats was significantly higher when the rats regained their righting reflex. While sedated, TRH in the medial septum of P rats was insignificantly increased. These data are the first to show that endogenous TRH in the medial septum may be involved in arousal from drug-induced sedation and that the events preceding arousal may occur sooner in P than in NP rats. In addition, innate differences in septal TRH may be associated with preference for ethanol.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalBrain Research Bulletin
Volume31
Issue number3-4
DOIs
StatePublished - 1993

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Keywords

  • Alcohol
  • Alcohol-preferring and alcohol-nonpreferring rats
  • Righting reflex
  • Sedation
  • Septum
  • TRH

ASJC Scopus subject areas

  • Neuroscience(all)

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