Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography

Mehreen Adhi, Denis Jusufbegovic, Shlomit Schaal

Research output: Contribution to journalArticle

Abstract

Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalOcular Immunology and Inflammation
Volume25
Issue number4
DOIs
StatePublished - Jul 4 2017
Externally publishedYes

Fingerprint

Histoplasmosis
Optical Coherence Tomography
Membranes
Control Groups
Retinal Pigment Epithelium

Keywords

  • Choroidal neovascular membrane
  • histo spots
  • pigment epithelial detachment
  • presumed ocular histoplasmosis syndrome
  • spectral-domain optical coherence tomography

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Cite this

Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography. / Adhi, Mehreen; Jusufbegovic, Denis; Schaal, Shlomit.

In: Ocular Immunology and Inflammation, Vol. 25, No. 4, 04.07.2017, p. 545-553.

Research output: Contribution to journalArticle

@article{f7e2b98a4cd544abae1bc5b001a5df91,
title = "Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography",
abstract = "Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100{\%}, and pigment epithelial detachment (PED) in 75{\%} of eyes. CNVM developed in 100{\%} of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100{\%} of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.",
keywords = "Choroidal neovascular membrane, histo spots, pigment epithelial detachment, presumed ocular histoplasmosis syndrome, spectral-domain optical coherence tomography",
author = "Mehreen Adhi and Denis Jusufbegovic and Shlomit Schaal",
year = "2017",
month = "7",
day = "4",
doi = "10.3109/09273948.2016.1158841",
language = "English (US)",
volume = "25",
pages = "545--553",
journal = "Ocular Immunology and Inflammation",
issn = "0927-3948",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography

AU - Adhi, Mehreen

AU - Jusufbegovic, Denis

AU - Schaal, Shlomit

PY - 2017/7/4

Y1 - 2017/7/4

N2 - Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.

AB - Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.

KW - Choroidal neovascular membrane

KW - histo spots

KW - pigment epithelial detachment

KW - presumed ocular histoplasmosis syndrome

KW - spectral-domain optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=84963847222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963847222&partnerID=8YFLogxK

U2 - 10.3109/09273948.2016.1158841

DO - 10.3109/09273948.2016.1158841

M3 - Article

VL - 25

SP - 545

EP - 553

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

SN - 0927-3948

IS - 4

ER -