Sequential thallium-201 myocardial scintigraphy after acute infarction in man. Comparison to creatine kinase-MB release pattern

James Fletcher, H. S. Mueller, P. S. Rao

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three sequential Tl-201 myocardial perfusion studies were performed in 21 patients (18 men, 3 women) with first acute transmural myocardial infarction. The Tl-201 image defect size was determined with a semiquantitative visual scoring method and temporal changes in image defect size were compared to CK-MB infarct size and enzymatic evidence of progressive myocardial necrosis and infarct extension. Progressive decreases in Tl-201 image defect size were observed and the visual score in all 21 patients decreased significantly from 6.5 ± 3.7 (mean ± SD) on day 1 to 4.9 ± 3.5 on day 12. Eleven patients without evidence of infarct extension had significantly lower infarct size, a significant decrease in visual score by the 12th day and had significantly smaller Tl-201 defects at all three study times compared to 10 patients with infarct extension. Seven of 10 (70%) with extension had an initial visual score ≥ 7 compared to only 2/11 (18%) without extension. The temporal behavior of Tl-201 image defects is related to the size of the infarction and presence or absence of extension. Sequential studies comparing early initial and subsequent defect size may assist in evaluating the behavior of ischemic and infarcted myocardium in the postinfarction period.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalRadiology
Volume136
Issue number1
StatePublished - 1980
Externally publishedYes

Fingerprint

MB Form Creatine Kinase
Myocardial Perfusion Imaging
Thallium
Infarction
Myocardial Infarction
Myocardium
Research Design
Necrosis
Perfusion

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Sequential thallium-201 myocardial scintigraphy after acute infarction in man. Comparison to creatine kinase-MB release pattern. / Fletcher, James; Mueller, H. S.; Rao, P. S.

In: Radiology, Vol. 136, No. 1, 1980, p. 191-195.

Research output: Contribution to journalArticle

@article{865877b3c97e4bd093fc562464a77e20,
title = "Sequential thallium-201 myocardial scintigraphy after acute infarction in man. Comparison to creatine kinase-MB release pattern",
abstract = "Three sequential Tl-201 myocardial perfusion studies were performed in 21 patients (18 men, 3 women) with first acute transmural myocardial infarction. The Tl-201 image defect size was determined with a semiquantitative visual scoring method and temporal changes in image defect size were compared to CK-MB infarct size and enzymatic evidence of progressive myocardial necrosis and infarct extension. Progressive decreases in Tl-201 image defect size were observed and the visual score in all 21 patients decreased significantly from 6.5 ± 3.7 (mean ± SD) on day 1 to 4.9 ± 3.5 on day 12. Eleven patients without evidence of infarct extension had significantly lower infarct size, a significant decrease in visual score by the 12th day and had significantly smaller Tl-201 defects at all three study times compared to 10 patients with infarct extension. Seven of 10 (70{\%}) with extension had an initial visual score ≥ 7 compared to only 2/11 (18{\%}) without extension. The temporal behavior of Tl-201 image defects is related to the size of the infarction and presence or absence of extension. Sequential studies comparing early initial and subsequent defect size may assist in evaluating the behavior of ischemic and infarcted myocardium in the postinfarction period.",
author = "James Fletcher and Mueller, {H. S.} and Rao, {P. S.}",
year = "1980",
language = "English (US)",
volume = "136",
pages = "191--195",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Sequential thallium-201 myocardial scintigraphy after acute infarction in man. Comparison to creatine kinase-MB release pattern

AU - Fletcher, James

AU - Mueller, H. S.

AU - Rao, P. S.

PY - 1980

Y1 - 1980

N2 - Three sequential Tl-201 myocardial perfusion studies were performed in 21 patients (18 men, 3 women) with first acute transmural myocardial infarction. The Tl-201 image defect size was determined with a semiquantitative visual scoring method and temporal changes in image defect size were compared to CK-MB infarct size and enzymatic evidence of progressive myocardial necrosis and infarct extension. Progressive decreases in Tl-201 image defect size were observed and the visual score in all 21 patients decreased significantly from 6.5 ± 3.7 (mean ± SD) on day 1 to 4.9 ± 3.5 on day 12. Eleven patients without evidence of infarct extension had significantly lower infarct size, a significant decrease in visual score by the 12th day and had significantly smaller Tl-201 defects at all three study times compared to 10 patients with infarct extension. Seven of 10 (70%) with extension had an initial visual score ≥ 7 compared to only 2/11 (18%) without extension. The temporal behavior of Tl-201 image defects is related to the size of the infarction and presence or absence of extension. Sequential studies comparing early initial and subsequent defect size may assist in evaluating the behavior of ischemic and infarcted myocardium in the postinfarction period.

AB - Three sequential Tl-201 myocardial perfusion studies were performed in 21 patients (18 men, 3 women) with first acute transmural myocardial infarction. The Tl-201 image defect size was determined with a semiquantitative visual scoring method and temporal changes in image defect size were compared to CK-MB infarct size and enzymatic evidence of progressive myocardial necrosis and infarct extension. Progressive decreases in Tl-201 image defect size were observed and the visual score in all 21 patients decreased significantly from 6.5 ± 3.7 (mean ± SD) on day 1 to 4.9 ± 3.5 on day 12. Eleven patients without evidence of infarct extension had significantly lower infarct size, a significant decrease in visual score by the 12th day and had significantly smaller Tl-201 defects at all three study times compared to 10 patients with infarct extension. Seven of 10 (70%) with extension had an initial visual score ≥ 7 compared to only 2/11 (18%) without extension. The temporal behavior of Tl-201 image defects is related to the size of the infarction and presence or absence of extension. Sequential studies comparing early initial and subsequent defect size may assist in evaluating the behavior of ischemic and infarcted myocardium in the postinfarction period.

UR - http://www.scopus.com/inward/record.url?scp=0018838892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018838892&partnerID=8YFLogxK

M3 - Article

C2 - 7384499

AN - SCOPUS:0018838892

VL - 136

SP - 191

EP - 195

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -