Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (hsp60)

J. N. Arno, Y. Yuan, R. E. Cleary, R. P. Morrison

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Objective: To determine whether women with Chlamydia trachomatis- associated tubal infertility are more likely than other infertile women to have antibodies to a particular region of the 60-kd chlamydial heat shock protein, hsp60. Design: Serologic responses to the chlamydial hsp60 were examined in 48 infertile women seropositive for Chlamydia trachomatis, including 21 women with tubal infertility, 13 women with endometriosis, and 9 women with other causes of infertility. Antibody responses were localized to regions of hsp60 using five nonoverlapping recombinant polypeptides. Results: Sixteen women with tubal infertility had anti-hsp60 antibodies compared with seven women with endometriosis and two women with other causes of infertility. Antibodies of 11 women with tubal infertility reacted predominantly with a region of hsp60 containing amino acids (201 to 300) compared with 1 woman without tubal infertility. In contrast, antibodies that localized to the carboxyl terminus, amino acids (401 to 544), were seen equally in all groups. Conclusions: Among seropositive infertile women, antibodies that localized to amino acids (201 to 300) were immunodominant in those with tubal infertility but not in those with infertility due to other causes.

Original languageEnglish (US)
Pages (from-to)730-735
Number of pages6
JournalFertility and Sterility
Volume64
Issue number4
StatePublished - Jan 1 1995

Keywords

  • Chlamydia trachomatis
  • Tubal infertility
  • antibody responses
  • heat shock proteins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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