Serotonin and dopamine systems regulating alcohol intake.

W. J. McBride, J. M. Murphy, G. J. Gatto, A. D. Levy, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

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Abstract

Neurochemical and neuropharmacological studies were undertaken to assess the involvement of CNS serotonin (5-HT) and dopamine (DA) pathways in regulating the alcohol intake of rats selectively bred for their high alcohol seeking behavior (P and HAD lines). Neurochemical data indicate that high alcohol seeking behavior (when compared with data from rats with low alcohol seeking characteristics) is associated with (a) lower contents of 5-HT in certain limbic regions, e.g., n. accumbens (Acb), frontal cortex, (b) a lower content of DA in the Acb, and (c) higher densities of 5-HT1A receptors in certain limbic regions, e.g., cerebral cortex. Neurochemical data also suggest that ethanol can activate the DA and 5-HT systems projecting to the Acb. Neuropharmacological studies demonstrated that local microinfusion of a 5-HT agonist into the Acb of the P line of rats enhanced ethanol drinking. Intracranial self-administration studies established that P rats will self-administer ethanol directly into the ventral tegmental area (VTA). Overall the data suggest the involvement of certain VTA DA and dorsal raphe nucleus 5-HT pathways in regulating high alcohol drinking behavior.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement
Volume1
StatePublished - 1991

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Dopamine
Serotonin
Alcohols
Ventral Tegmental Area
Ethanol
Serotonin Receptor Agonists
Drinking Behavior
Receptor, Serotonin, 5-HT1A
Self Administration
Frontal Lobe
Alcohol Drinking
Cerebral Cortex
Drinking

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McBride, W. J., Murphy, J. M., Gatto, G. J., Levy, A. D., Lumeng, L., & Li, T. K. (1991). Serotonin and dopamine systems regulating alcohol intake. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 411-416.

Serotonin and dopamine systems regulating alcohol intake. / McBride, W. J.; Murphy, J. M.; Gatto, G. J.; Levy, A. D.; Lumeng, L.; Li, T. K.

In: Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, Vol. 1, 1991, p. 411-416.

Research output: Contribution to journalArticle

McBride, WJ, Murphy, JM, Gatto, GJ, Levy, AD, Lumeng, L & Li, TK 1991, 'Serotonin and dopamine systems regulating alcohol intake.', Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, vol. 1, pp. 411-416.
McBride WJ, Murphy JM, Gatto GJ, Levy AD, Lumeng L, Li TK. Serotonin and dopamine systems regulating alcohol intake. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 1991;1:411-416.
McBride, W. J. ; Murphy, J. M. ; Gatto, G. J. ; Levy, A. D. ; Lumeng, L. ; Li, T. K. / Serotonin and dopamine systems regulating alcohol intake. In: Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 1991 ; Vol. 1. pp. 411-416.
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