Serotonin content is elevated in the dopamine deficient striatum of the weaver mutant mouse

E. H. Stotz, L. C. Triarhou, B. Ghetti, J. R. Simon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In the present study, we measured the striatal serotonin content of weaver and control mice at different ages. Overall, weaver mutant mice exhibited 50% more striatal serotonin than controls. Neither a rostrocaudal gradient nor an age effect was found for either genotype. An analysis of serotonin content across the dorsoventral extent of the striatum revealed that in the dorsal striatum of the weaver, serotonin content was increased 200%, and in the ventral striatum, the increase amounted to 50% relative to control mice. Serotonin immunocytochemistry also revealed an increase in the dorsal striata of weaver mice. The major increase in striatal serotonin content seen in the weaver striatum occurs in the same region that exhibits the severest dopamine depletion. This observation is consistent with the notion that the increase in serotonin levels may be secondary to the decrease in dopamine content and may play an adaptive or compensatory role.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalBrain research
Volume606
Issue number2
DOIs
StatePublished - Mar 26 1993

Keywords

  • Immunocytochemistry
  • Serotonin
  • Striatum
  • Weaver mutant mouse

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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