Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree

Liana C. Del Gobbo, Yiqing Song, David A. Dannenbaum, Eric Dewailly, Grace M. Egeland

Research output: Contribution to journalArticle

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Abstract

Epidemiological studies report inverse associations between blood vitamin D, as measured by 25-hydroxyvitamin D [25 (OH)D] concentrations, and insulin resistance (IR) among predominantly overweight individuals. In a cross-sectional survey of 5 Cree communities in Quebec, Canada, we determined if 25(OH)D is associated with IR and β-cell function in a largely obese, ethnic minority at high risk of developing type 2 diabetes. A total of 510 participants (≥18 y) without type 1 or type 2 diabetes, assessed for serum 25(OH)D, fasting plasma glucose and insulin, and anthropometric and lifestyle variables, were included in the analyses. Multivariable linear regressions adjusted for covariates were performed for homeostasis model assessment of IR (HOMA-IR) and β-cell function (HOMA-B) in relation to serum 25(OH)D. Serum 25(OH)D (per 10 nmol/L increment) was inversely associated with HOMA-IR (β = 20.005; SE = 0.002; P = 0.004) and HOMA-B (β = -0.004; SE = 0.002; P = 0.006) in models adjusted for age, sex, physical activity, education, alcohol consumption, and smoking. When further adjusted for BMI, associations were no longer significant for either HOMA-IR (β = 0.001, SE = 0.002, P = 0.572) or HOMA-B (β = 0.001, SE = 0.001, P = 0.498). The modest inverse associations between 25(OH)D and IR reported previously were not observed in this population after adjusting for adiposity. Future longitudinal studies investigating the interrelationship among 25(OH)D, adiposity, and the risk of developing metabolic syndrome and type 2 diabetes are warranted.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalJournal of Nutrition
Volume141
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

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Insulin Resistance
Type 2 Diabetes Mellitus
Homeostasis
Adiposity
Serum
Physical Education and Training
Quebec
Vitamin D
Alcohol Drinking
Canada
Longitudinal Studies
Life Style
Epidemiologic Studies
Linear Models
Fasting
Cross-Sectional Studies
Smoking
Insulin
Glucose
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree. / Del Gobbo, Liana C.; Song, Yiqing; Dannenbaum, David A.; Dewailly, Eric; Egeland, Grace M.

In: Journal of Nutrition, Vol. 141, No. 2, 01.02.2011, p. 290-295.

Research output: Contribution to journalArticle

Del Gobbo, Liana C. ; Song, Yiqing ; Dannenbaum, David A. ; Dewailly, Eric ; Egeland, Grace M. / Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree. In: Journal of Nutrition. 2011 ; Vol. 141, No. 2. pp. 290-295.
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