Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma

P. H. Lange, L. E. Nochomovitz, J. Rosai, E. E. Fraley, B. J. Kennedy, G. Bosl, J. Brisbane, W. J. Catalona, J. S. Cochran, R. H. Comisarow, K. B. Cummings, J. B. deKernion, Lawrence Einhorn, T. R. Hakala, M. Jewett, M. R. Moore, P. T. Scardino, J. M. Streitz

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Abstract

We analyzed the case histories of 31 patients who initially had a diagnosis of seminoma and elevated serum levels of alpha-fetoprotein or human chorionic gonadotropin. We concluded that an elevated alpha-fetoprotein level is firm evidence of the presence of non-seminomatous germ cell tumor and that the patient should be treated accordingly. However, if the level of human chorionic gonadotropin alone is elevated the diagnosis may be either non-seminomatous tumor or seminoma. Patients with seminoma and an elevated level of human chorionic gonadotropin do respond well to radiation therapy if they have low stage disease but if metastatic seminoma is present an elevated human chorionic gonadotropin level appears to be a poor prognostic sign if conventional treatment is given. A plan of treatment is proposed for these patients.

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalJournal of Urology
Volume124
Issue number4
StatePublished - 1980
Externally publishedYes

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Alpha Subunit Glycoprotein Hormones
Seminoma
alpha-Fetoproteins
Chorionic Gonadotropin
Serum
Radiotherapy
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Lange, P. H., Nochomovitz, L. E., Rosai, J., Fraley, E. E., Kennedy, B. J., Bosl, G., ... Streitz, J. M. (1980). Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. Journal of Urology, 124(4), 472-478.

Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. / Lange, P. H.; Nochomovitz, L. E.; Rosai, J.; Fraley, E. E.; Kennedy, B. J.; Bosl, G.; Brisbane, J.; Catalona, W. J.; Cochran, J. S.; Comisarow, R. H.; Cummings, K. B.; deKernion, J. B.; Einhorn, Lawrence; Hakala, T. R.; Jewett, M.; Moore, M. R.; Scardino, P. T.; Streitz, J. M.

In: Journal of Urology, Vol. 124, No. 4, 1980, p. 472-478.

Research output: Contribution to journalArticle

Lange, PH, Nochomovitz, LE, Rosai, J, Fraley, EE, Kennedy, BJ, Bosl, G, Brisbane, J, Catalona, WJ, Cochran, JS, Comisarow, RH, Cummings, KB, deKernion, JB, Einhorn, L, Hakala, TR, Jewett, M, Moore, MR, Scardino, PT & Streitz, JM 1980, 'Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma', Journal of Urology, vol. 124, no. 4, pp. 472-478.
Lange PH, Nochomovitz LE, Rosai J, Fraley EE, Kennedy BJ, Bosl G et al. Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. Journal of Urology. 1980;124(4):472-478.
Lange, P. H. ; Nochomovitz, L. E. ; Rosai, J. ; Fraley, E. E. ; Kennedy, B. J. ; Bosl, G. ; Brisbane, J. ; Catalona, W. J. ; Cochran, J. S. ; Comisarow, R. H. ; Cummings, K. B. ; deKernion, J. B. ; Einhorn, Lawrence ; Hakala, T. R. ; Jewett, M. ; Moore, M. R. ; Scardino, P. T. ; Streitz, J. M. / Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. In: Journal of Urology. 1980 ; Vol. 124, No. 4. pp. 472-478.
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AU - Nochomovitz, L. E.

AU - Rosai, J.

AU - Fraley, E. E.

AU - Kennedy, B. J.

AU - Bosl, G.

AU - Brisbane, J.

AU - Catalona, W. J.

AU - Cochran, J. S.

AU - Comisarow, R. H.

AU - Cummings, K. B.

AU - deKernion, J. B.

AU - Einhorn, Lawrence

AU - Hakala, T. R.

AU - Jewett, M.

AU - Moore, M. R.

AU - Scardino, P. T.

AU - Streitz, J. M.

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AB - We analyzed the case histories of 31 patients who initially had a diagnosis of seminoma and elevated serum levels of alpha-fetoprotein or human chorionic gonadotropin. We concluded that an elevated alpha-fetoprotein level is firm evidence of the presence of non-seminomatous germ cell tumor and that the patient should be treated accordingly. However, if the level of human chorionic gonadotropin alone is elevated the diagnosis may be either non-seminomatous tumor or seminoma. Patients with seminoma and an elevated level of human chorionic gonadotropin do respond well to radiation therapy if they have low stage disease but if metastatic seminoma is present an elevated human chorionic gonadotropin level appears to be a poor prognostic sign if conventional treatment is given. A plan of treatment is proposed for these patients.

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