Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum

M. Skinner, J. L. Vaitukaitis, A. S. Cohen, Merrill Benson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalJournal of Laboratory and Clinical Medicine
Volume94
Issue number4
StatePublished - 1979
Externally publishedYes

Fingerprint

Serum Amyloid P-Component
Connective Tissue Diseases
Acute-Phase Proteins
Amyloidosis
Tissue
Infection
Serum
Neoplasms
Bacterial Pneumonia
Radioimmunoassay
Reference Values

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum. / Skinner, M.; Vaitukaitis, J. L.; Cohen, A. S.; Benson, Merrill.

In: Journal of Laboratory and Clinical Medicine, Vol. 94, No. 4, 1979, p. 633-638.

Research output: Contribution to journalArticle

@article{bff046e7905544fc8598237aa5fbf68c,
title = "Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum",
abstract = "A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.",
author = "M. Skinner and Vaitukaitis, {J. L.} and Cohen, {A. S.} and Merrill Benson",
year = "1979",
language = "English (US)",
volume = "94",
pages = "633--638",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum

AU - Skinner, M.

AU - Vaitukaitis, J. L.

AU - Cohen, A. S.

AU - Benson, Merrill

PY - 1979

Y1 - 1979

N2 - A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.

AB - A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.

UR - http://www.scopus.com/inward/record.url?scp=0018717327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018717327&partnerID=8YFLogxK

M3 - Article

VL - 94

SP - 633

EP - 638

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 4

ER -