Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum

M. Skinner, J. L. Vaitukaitis, A. S. Cohen, M. D. Benson

Research output: Contribution to journalArticle

35 Scopus citations


A highly sensitive radioimmunoassay was developed to measure the serum levels of SAP. Sera from 50 normal individuals ranging in age from 4 to 89 years had a mean level of 7.47 mg/dl and showed no variations with age. Sera from persons with various clinical types of amyloidosis, connective tissue diseases, and bacterial pneumonia did not differ significantly from normal values. A significant difference was noted in the sera from persons with malignancy, where a mean value of 10.79 mg/dl was determined. Although a number of similarities exist between SAP and CRP, SAP does not share the property of being an acute-phase reactant.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalJournal of Laboratory and Clinical Medicine
Issue number4
StatePublished - Dec 1 1979


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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