Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans

R. M. Evans, C. L. Emsley, S. Gao, A. Sahota, K. S. Hall, M. R. Farlow, Hugh C. Hendrie

Research output: Contribution to journalArticle

163 Scopus citations


A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no ε4 alleles, whereas TC was not associated with increased AD risk in the group with one or more ε4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
Issue number1
StatePublished - Jan 11 2000



  • AD
  • African American
  • APOE genotype
  • Cholesterol

ASJC Scopus subject areas

  • Neuroscience(all)

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