Serum corticosterone increases reflect enhanced uptake inhibitor-induced elevation of extracellular 5-hydroxytryptamine in rat hypothalamus

Ray W. Fuller, Kenneth W. Perry, Susan K. Hemrick-Luecke, Eric Engleman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The increase in extracellular 5-hydroxytryptamine (5-HT) in rat hypothalamus following administration of fluoxetine, a 5-HT-uptake inhibitor, was enhanced by the injection of LY206130 (1-[ 1-H-indol-4-yloxy]-3-[cyclohexylamino]-2-propanol maleate), a 5HT(1A) receptor antagonist, or by L-5-hydroxytrygtophiln (L-5HTP), the 5-HT precursor. Elevation of serum corticosterone, measured as a functional output of hypothalamic 5-HT pathways, was greater in rats treated with fluoxetine plus LY206130 or with fluoxetine plus L-5-HTF than in rats treated with the agents alone. Synergism between effects of fluoxetine and L-5HTF has often been reported, but this is the first report of an increased functional effect when a 5-HT(1A) receptor antagonist is combined with a 5-HT uptake inhibitor to augment the increase in extracellular 5-HT.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume48
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Fluoxetine
LY 206130
Corticosterone
Hypothalamus
Serotonin
Serotonin Uptake Inhibitors
Serum
Receptor, Serotonin, 5-HT1A
2-Propanol
Injections

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Serum corticosterone increases reflect enhanced uptake inhibitor-induced elevation of extracellular 5-hydroxytryptamine in rat hypothalamus. / Fuller, Ray W.; Perry, Kenneth W.; Hemrick-Luecke, Susan K.; Engleman, Eric.

In: Journal of Pharmacy and Pharmacology, Vol. 48, No. 1, 1996, p. 68-70.

Research output: Contribution to journalArticle

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