The increase in extracellular 5-hydroxytryptamine (5-HT) in rat hypothalamus following administration of fluoxetine, a 5-HT-uptake inhibitor, was enhanced by the injection of LY206130 (1-[ 1-H-indol-4-yloxy]-3-[cyclohexylamino]-2-propanol maleate), a 5HT(1A) receptor antagonist, or by L-5-hydroxytrygtophiln (L-5HTP), the 5-HT precursor. Elevation of serum corticosterone, measured as a functional output of hypothalamic 5-HT pathways, was greater in rats treated with fluoxetine plus LY206130 or with fluoxetine plus L-5-HTF than in rats treated with the agents alone. Synergism between effects of fluoxetine and L-5HTF has often been reported, but this is the first report of an increased functional effect when a 5-HT(1A) receptor antagonist is combined with a 5-HT uptake inhibitor to augment the increase in extracellular 5-HT.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Pharmacy and Pharmacology|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Pharmaceutical Science