Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women

Erik Imel, Ziyue Liu, Amie K. McQueen, Dena Acton, Anthony Acton, Leah R. Padgett, Munro Peacock, Michael Econs

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associate with bone mineral density (BMD).Serum iron, iron binding capacity, percent iron saturation, phosphorus, and other biochemistries were measured in stored fasting samples from healthy premenopausal white (n = 1898) and black women (n = 994), age 20-55 years. Serum C-terminal and intact FGF23 were measured in a subset (1631 white and 296 black women). BMD was measured at the lumbar spine and femur neck.Serum phosphorus, calcium, alkaline phosphatase and creatinine were lower in white women than black women (p <0.001). Serum iron (p <0.0001) and intact FGF23 (p <0.01) were higher in white women. C-terminal FGF23 did not differ between races. Phosphorus correlated with intact FGF23 (white women, r = 0.120, p <0.0001; black women r = 0.163, p <0.01). However, phosphorus correlated with C-terminal FGF23 only in black women (r = 0.157, p <0.01). Intact FGF23 did not correlate with iron. C-terminal FGF23 correlated inversely with iron (white women r = - 0.134, p <0.0001; black women r = - 0.188, p <0.01), having a steeper slope at iron

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalBone
Volume86
DOIs
StatePublished - May 1 2016

Fingerprint

Bone Density
Iron
Serum
Phosphorus
fibroblast growth factor 23
Femur Neck
Biochemistry
Alkaline Phosphatase
Fasting
Creatinine
Spine
Calcium
Gene Expression

Keywords

  • Bone mineral density
  • DXA
  • FGF23
  • Fibroblast growth factor 23
  • Iron
  • Premenopausal women

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women. / Imel, Erik; Liu, Ziyue; McQueen, Amie K.; Acton, Dena; Acton, Anthony; Padgett, Leah R.; Peacock, Munro; Econs, Michael.

In: Bone, Vol. 86, 01.05.2016, p. 98-105.

Research output: Contribution to journalArticle

Imel, Erik ; Liu, Ziyue ; McQueen, Amie K. ; Acton, Dena ; Acton, Anthony ; Padgett, Leah R. ; Peacock, Munro ; Econs, Michael. / Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women. In: Bone. 2016 ; Vol. 86. pp. 98-105.
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