Serum IgE and human immunodeficiency virus (HIV) infection

David N. Wright, Robert Nelson, Dennis K. Ledford, Enrique Fernandez-Caldas, Walter L. Trudeau, Richard F. Lockey

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Human immunodeficiency virus infection is characterized by a progressive depletion of helper T-lymphocyes and, like allergic diseases, is associated with altered T cell regulation. Total serum IgE was measured in 67 infected male subjects, 27 uninfected heterosexual male subjects, and 18 uninfected homosexual male subjects. The mean IgE level (132 IU/ml) of infected subjects with a helper T-lymphocyte number ≤200/mm3 was significantly greater than mean IgE levels of the uninfected heterosexual (38 IU/ml) and homosexual (35 IU/ml) groups. IgE levels were inversely related to both helper T cell and suppressor/cytotoxic T cell numbers but not to IgG or IgA levels. The increase in IgE was not a reflection of an increased prevalence of atopic disease (allergic asthma, allergic rhinitis, or atopic dermatitis) in the infected subjects. The elevation of IgE may be related to a difference among the groups in T cell production of IgE regulatory lymphokines.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume85
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Virus Diseases
Immunoglobulin E
HIV
Serum
Heterosexuality
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Lymphokines
Lymphocyte Count
Atopic Dermatitis
Immunoglobulin A
Asthma
Cell Count
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Wright, D. N., Nelson, R., Ledford, D. K., Fernandez-Caldas, E., Trudeau, W. L., & Lockey, R. F. (1990). Serum IgE and human immunodeficiency virus (HIV) infection. Journal of Allergy and Clinical Immunology, 85(2), 445-452. https://doi.org/10.1016/0091-6749(90)90154-V

Serum IgE and human immunodeficiency virus (HIV) infection. / Wright, David N.; Nelson, Robert; Ledford, Dennis K.; Fernandez-Caldas, Enrique; Trudeau, Walter L.; Lockey, Richard F.

In: Journal of Allergy and Clinical Immunology, Vol. 85, No. 2, 1990, p. 445-452.

Research output: Contribution to journalArticle

Wright, DN, Nelson, R, Ledford, DK, Fernandez-Caldas, E, Trudeau, WL & Lockey, RF 1990, 'Serum IgE and human immunodeficiency virus (HIV) infection', Journal of Allergy and Clinical Immunology, vol. 85, no. 2, pp. 445-452. https://doi.org/10.1016/0091-6749(90)90154-V
Wright, David N. ; Nelson, Robert ; Ledford, Dennis K. ; Fernandez-Caldas, Enrique ; Trudeau, Walter L. ; Lockey, Richard F. / Serum IgE and human immunodeficiency virus (HIV) infection. In: Journal of Allergy and Clinical Immunology. 1990 ; Vol. 85, No. 2. pp. 445-452.
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