Serum IgE and human immunodeficiency virus (HIV) infection

David N. Wright, Robert P. Nelson, Dennis K. Ledford, Enrique Fernandez-Caldas, Walter L. Trudeau, Richard F. Lockey

Research output: Contribution to journalArticle

114 Scopus citations


Human immunodeficiency virus infection is characterized by a progressive depletion of helper T-lymphocyes and, like allergic diseases, is associated with altered T cell regulation. Total serum IgE was measured in 67 infected male subjects, 27 uninfected heterosexual male subjects, and 18 uninfected homosexual male subjects. The mean IgE level (132 IU/ml) of infected subjects with a helper T-lymphocyte number ≤200/mm3 was significantly greater than mean IgE levels of the uninfected heterosexual (38 IU/ml) and homosexual (35 IU/ml) groups. IgE levels were inversely related to both helper T cell and suppressor/cytotoxic T cell numbers but not to IgG or IgA levels. The increase in IgE was not a reflection of an increased prevalence of atopic disease (allergic asthma, allergic rhinitis, or atopic dermatitis) in the infected subjects. The elevation of IgE may be related to a difference among the groups in T cell production of IgE regulatory lymphokines.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Issue number2
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Wright, D. N., Nelson, R. P., Ledford, D. K., Fernandez-Caldas, E., Trudeau, W. L., & Lockey, R. F. (1990). Serum IgE and human immunodeficiency virus (HIV) infection. The Journal of Allergy and Clinical Immunology, 85(2), 445-452.