Serum immunoreactive-leptin concentrations in normal-weight and obese humans

Robert Considine, Madhur K. Sinha, Mark L. Heiman, Aidas Kriauciunas, Thomas W. Stephens, Mark R. Nyce, Joanna P. Ohannesian, Cheryl C. Marco, Linda J. Mckee, Thomas L. Bauer, José F. Caro

Research output: Contribution to journalArticle

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Abstract

Background. Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the physiologic actions of leptin in humans. Methods. Using a newly developed radioimmunoassay, we measured serum concentrations of leptin in 136 normal-weight subjects and 139 obese subjects (body-mass index, ≥27.3 for men and ≥27.8 for women; the body-mass index was defined as the weight in kilograms divided by the square of the height in meters). The measurements were repeated in seven obese subjects after weight loss and during maintenance of the lower weight. The ob messenger RNA (mRNA) content of adipocytes was determined in 27 normal- weight and 27 obese subjects. Results. The mean (±SD) serum leptin concentrations were 31.3±24.1 ng per milliliter in the obese subjects and 7.5±9.3 ng per milliliter in the normal-weight subjects (P

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalNew England Journal of Medicine
Volume334
Issue number5
DOIs
StatePublished - Feb 1 1996
Externally publishedYes

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Leptin
Weights and Measures
Serum
Adipocytes
Body Mass Index
Radioimmunoassay
Weight Loss
Maintenance
Hormones
Messenger RNA
Mutation
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Considine, R., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., ... Caro, J. F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334(5), 292-295. https://doi.org/10.1056/NEJM199602013340503

Serum immunoreactive-leptin concentrations in normal-weight and obese humans. / Considine, Robert; Sinha, Madhur K.; Heiman, Mark L.; Kriauciunas, Aidas; Stephens, Thomas W.; Nyce, Mark R.; Ohannesian, Joanna P.; Marco, Cheryl C.; Mckee, Linda J.; Bauer, Thomas L.; Caro, José F.

In: New England Journal of Medicine, Vol. 334, No. 5, 01.02.1996, p. 292-295.

Research output: Contribution to journalArticle

Considine, R, Sinha, MK, Heiman, ML, Kriauciunas, A, Stephens, TW, Nyce, MR, Ohannesian, JP, Marco, CC, Mckee, LJ, Bauer, TL & Caro, JF 1996, 'Serum immunoreactive-leptin concentrations in normal-weight and obese humans', New England Journal of Medicine, vol. 334, no. 5, pp. 292-295. https://doi.org/10.1056/NEJM199602013340503
Considine, Robert ; Sinha, Madhur K. ; Heiman, Mark L. ; Kriauciunas, Aidas ; Stephens, Thomas W. ; Nyce, Mark R. ; Ohannesian, Joanna P. ; Marco, Cheryl C. ; Mckee, Linda J. ; Bauer, Thomas L. ; Caro, José F. / Serum immunoreactive-leptin concentrations in normal-weight and obese humans. In: New England Journal of Medicine. 1996 ; Vol. 334, No. 5. pp. 292-295.
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