Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome

A. Leal-Cerro, Robert Considine, R. Peino, E. Venegas, R. Astorga, F. F. Casanueva, C. Dieguez

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Cushing's syndrome is a disease state usually associated with weight gain due to the accumulation of adipose tissue. In order to study the effect of chronic glucocorticoid excess upon serum leptin levels; in the present work, four patients with recently diagnosed Cushing's syndrome and a group of control subjects matched for age, sex and body mass index (BMI) were studied. Serum leptin concentrations, measured by radioimmunoassay, were assessed in samples taken every 60 minutes over a 24 hour period. Assessment of leptin concentrations over 24 hours, by means of the area under curve showed a twofold increase in serum leptin levels in patients with Cushing's syndrome (mean ± SEM 54.3 ± 14) in comparison to control subjects (29.3 ± 4.4; p <0.05). In conclusion, our data show that leptin levels are markedly increased in Cushing's syndrome patients. The relevance of this finding to the increased body fat present in patients with Cushing's syndrome merits further studies.

Original languageEnglish (US)
Pages (from-to)711-713
Number of pages3
JournalHormone and Metabolic Research
Volume28
Issue number12
StatePublished - 1996
Externally publishedYes

Fingerprint

Cushing Syndrome
Leptin
Serum
Adipose Tissue
Adipocytes
Glucocorticoids
Weight Gain
Area Under Curve
Radioimmunoassay
Body Mass Index
Fats
Hormones
Tissue
Control Groups
Scanning electron microscopy

Keywords

  • adipose tissue
  • food intake
  • glucocorticoids
  • obesity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Leal-Cerro, A., Considine, R., Peino, R., Venegas, E., Astorga, R., Casanueva, F. F., & Dieguez, C. (1996). Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. Hormone and Metabolic Research, 28(12), 711-713.

Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. / Leal-Cerro, A.; Considine, Robert; Peino, R.; Venegas, E.; Astorga, R.; Casanueva, F. F.; Dieguez, C.

In: Hormone and Metabolic Research, Vol. 28, No. 12, 1996, p. 711-713.

Research output: Contribution to journalArticle

Leal-Cerro, A, Considine, R, Peino, R, Venegas, E, Astorga, R, Casanueva, FF & Dieguez, C 1996, 'Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome', Hormone and Metabolic Research, vol. 28, no. 12, pp. 711-713.
Leal-Cerro A, Considine R, Peino R, Venegas E, Astorga R, Casanueva FF et al. Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. Hormone and Metabolic Research. 1996;28(12):711-713.
Leal-Cerro, A. ; Considine, Robert ; Peino, R. ; Venegas, E. ; Astorga, R. ; Casanueva, F. F. ; Dieguez, C. / Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. In: Hormone and Metabolic Research. 1996 ; Vol. 28, No. 12. pp. 711-713.
@article{dd35e10c2294424bb192ebbed31fe2c7,
title = "Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome",
abstract = "Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Cushing's syndrome is a disease state usually associated with weight gain due to the accumulation of adipose tissue. In order to study the effect of chronic glucocorticoid excess upon serum leptin levels; in the present work, four patients with recently diagnosed Cushing's syndrome and a group of control subjects matched for age, sex and body mass index (BMI) were studied. Serum leptin concentrations, measured by radioimmunoassay, were assessed in samples taken every 60 minutes over a 24 hour period. Assessment of leptin concentrations over 24 hours, by means of the area under curve showed a twofold increase in serum leptin levels in patients with Cushing's syndrome (mean ± SEM 54.3 ± 14) in comparison to control subjects (29.3 ± 4.4; p <0.05). In conclusion, our data show that leptin levels are markedly increased in Cushing's syndrome patients. The relevance of this finding to the increased body fat present in patients with Cushing's syndrome merits further studies.",
keywords = "adipose tissue, food intake, glucocorticoids, obesity",
author = "A. Leal-Cerro and Robert Considine and R. Peino and E. Venegas and R. Astorga and Casanueva, {F. F.} and C. Dieguez",
year = "1996",
language = "English (US)",
volume = "28",
pages = "711--713",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",
publisher = "Georg Thieme Verlag",
number = "12",

}

TY - JOUR

T1 - Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome

AU - Leal-Cerro, A.

AU - Considine, Robert

AU - Peino, R.

AU - Venegas, E.

AU - Astorga, R.

AU - Casanueva, F. F.

AU - Dieguez, C.

PY - 1996

Y1 - 1996

N2 - Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Cushing's syndrome is a disease state usually associated with weight gain due to the accumulation of adipose tissue. In order to study the effect of chronic glucocorticoid excess upon serum leptin levels; in the present work, four patients with recently diagnosed Cushing's syndrome and a group of control subjects matched for age, sex and body mass index (BMI) were studied. Serum leptin concentrations, measured by radioimmunoassay, were assessed in samples taken every 60 minutes over a 24 hour period. Assessment of leptin concentrations over 24 hours, by means of the area under curve showed a twofold increase in serum leptin levels in patients with Cushing's syndrome (mean ± SEM 54.3 ± 14) in comparison to control subjects (29.3 ± 4.4; p <0.05). In conclusion, our data show that leptin levels are markedly increased in Cushing's syndrome patients. The relevance of this finding to the increased body fat present in patients with Cushing's syndrome merits further studies.

AB - Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes. Cushing's syndrome is a disease state usually associated with weight gain due to the accumulation of adipose tissue. In order to study the effect of chronic glucocorticoid excess upon serum leptin levels; in the present work, four patients with recently diagnosed Cushing's syndrome and a group of control subjects matched for age, sex and body mass index (BMI) were studied. Serum leptin concentrations, measured by radioimmunoassay, were assessed in samples taken every 60 minutes over a 24 hour period. Assessment of leptin concentrations over 24 hours, by means of the area under curve showed a twofold increase in serum leptin levels in patients with Cushing's syndrome (mean ± SEM 54.3 ± 14) in comparison to control subjects (29.3 ± 4.4; p <0.05). In conclusion, our data show that leptin levels are markedly increased in Cushing's syndrome patients. The relevance of this finding to the increased body fat present in patients with Cushing's syndrome merits further studies.

KW - adipose tissue

KW - food intake

KW - glucocorticoids

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=0030478339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030478339&partnerID=8YFLogxK

M3 - Article

C2 - 9013748

AN - SCOPUS:0030478339

VL - 28

SP - 711

EP - 713

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

IS - 12

ER -