Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia

Burke J. Brooks, Hal Broxmeyer, Christopher F. Bryan, Stephen H. Leech

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient’s disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

Original languageEnglish (US)
Pages (from-to)1474-1477
Number of pages4
JournalArchives of Internal Medicine
Volume144
Issue number7
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Aplastic Anemia
Systemic Lupus Erythematosus
Granulocyte-Macrophage Progenitor Cells
Plasmapheresis
Serum
Immunosuppression
Immunoglobulin G
Bone Marrow
Tissue Donors
Antibodies
Growth
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia. / Brooks, Burke J.; Broxmeyer, Hal; Bryan, Christopher F.; Leech, Stephen H.

In: Archives of Internal Medicine, Vol. 144, No. 7, 1984, p. 1474-1477.

Research output: Contribution to journalArticle

Brooks, Burke J. ; Broxmeyer, Hal ; Bryan, Christopher F. ; Leech, Stephen H. / Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia. In: Archives of Internal Medicine. 1984 ; Vol. 144, No. 7. pp. 1474-1477.
@article{792aed94e7ef429f9ef5b862e94030ca,
title = "Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia",
abstract = "Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient’s disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.",
author = "Brooks, {Burke J.} and Hal Broxmeyer and Bryan, {Christopher F.} and Leech, {Stephen H.}",
year = "1984",
doi = "10.1001/archinte.1984.00350190172030",
language = "English (US)",
volume = "144",
pages = "1474--1477",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia

AU - Brooks, Burke J.

AU - Broxmeyer, Hal

AU - Bryan, Christopher F.

AU - Leech, Stephen H.

PY - 1984

Y1 - 1984

N2 - Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient’s disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

AB - Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient’s disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

UR - http://www.scopus.com/inward/record.url?scp=0021247313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021247313&partnerID=8YFLogxK

U2 - 10.1001/archinte.1984.00350190172030

DO - 10.1001/archinte.1984.00350190172030

M3 - Article

VL - 144

SP - 1474

EP - 1477

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 7

ER -