Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia

Burke J. Brooks, Hal E. Broxmeyer, Christopher F. Bryan, Stephen H. Leech

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Abstract

Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient’s disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

Original languageEnglish (US)
Pages (from-to)1474-1477
Number of pages4
JournalArchives of Internal Medicine
Volume144
Issue number7
DOIs
StatePublished - Jul 1984

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ASJC Scopus subject areas

  • Internal Medicine

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