Serum leptin levels and energy expenditure in normal weight women

L. J. Martin, P. J.H. Jones, R. V. Considine, W. Su, N. F. Boyd, J. F. Caro

Research output: Contribution to journalArticle

25 Scopus citations


To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r= 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalCanadian Journal of Physiology and Pharmacology
Issue number2
StatePublished - Jan 1 1998
Externally publishedYes


  • Body composition
  • Diet
  • Energy expenditure
  • Leptin

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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