Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites

Tara M. Vogt, S. T. Mayne, B. I. Graubard, C. A. Swanson, A. L. Sowell, J. B. Schoenberg, G. M. Swanson, R. S. Greenberg, R. N. Hoover, R. B. Hayes, R. G. Ziegler

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Epidemiologic studies investigating the relation between individual carotenoids and risk of prostate cancer have produced inconsistent results. To further explore these associations and to search for reasons prostate cancer incidence is over 50% higher in US Blacks than Whites, the authors analyzed the serum levels of individual carotenoids in 209 cases and 228 controls in a US multicenter, population-based case-control study (1986-1989) that included comparable numbers of Black men and White men aged 40-79 years. Lycopene was inversely associated with prostate cancer risk (comparing highest with lowest quartiles, odds ratio (OR) = 0.65, 95% confidence interval (CI): 0.36, 1.15; test for trend, p = 0.09), particularly for aggressive disease (comparing extreme quartiles, OR = 0.37, 95% Cl: 0.15, 0.94; test for trend, p = 0.04). Other carotenoids were positively associated with risk. For all carotenoids, patterns were similar for Blacks and Whites. However, in both the controls and the Third National Health and Nutrition Examination Survey, serum lycopene concentrations were significantly lower in Blacks than in Whites, raising the possibility that differences in lycopene exposure may contribute to the racial disparity in incidence. In conclusion, the results, though not statistically significant, suggest that serum lycopene is inversely related to prostate cancer risk in US Blacks and Whites.

Original languageEnglish (US)
Pages (from-to)1023-1032
Number of pages10
JournalAmerican Journal of Epidemiology
Volume155
Issue number11
DOIs
StatePublished - Jun 1 2002
Externally publishedYes

Fingerprint

Carotenoids
Prostatic Neoplasms
Serum
Odds Ratio
Nutrition Surveys
Incidence
Case-Control Studies
Epidemiologic Studies
lycopene
hydroquinone
Confidence Intervals
Population

Keywords

  • Blacks
  • Carotenoids
  • Case-control studies
  • Nutrition
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Vogt, T. M., Mayne, S. T., Graubard, B. I., Swanson, C. A., Sowell, A. L., Schoenberg, J. B., ... Ziegler, R. G. (2002). Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. American Journal of Epidemiology, 155(11), 1023-1032. https://doi.org/10.1093/aje/155.11.1023

Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. / Vogt, Tara M.; Mayne, S. T.; Graubard, B. I.; Swanson, C. A.; Sowell, A. L.; Schoenberg, J. B.; Swanson, G. M.; Greenberg, R. S.; Hoover, R. N.; Hayes, R. B.; Ziegler, R. G.

In: American Journal of Epidemiology, Vol. 155, No. 11, 01.06.2002, p. 1023-1032.

Research output: Contribution to journalArticle

Vogt, TM, Mayne, ST, Graubard, BI, Swanson, CA, Sowell, AL, Schoenberg, JB, Swanson, GM, Greenberg, RS, Hoover, RN, Hayes, RB & Ziegler, RG 2002, 'Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites', American Journal of Epidemiology, vol. 155, no. 11, pp. 1023-1032. https://doi.org/10.1093/aje/155.11.1023
Vogt TM, Mayne ST, Graubard BI, Swanson CA, Sowell AL, Schoenberg JB et al. Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. American Journal of Epidemiology. 2002 Jun 1;155(11):1023-1032. https://doi.org/10.1093/aje/155.11.1023
Vogt, Tara M. ; Mayne, S. T. ; Graubard, B. I. ; Swanson, C. A. ; Sowell, A. L. ; Schoenberg, J. B. ; Swanson, G. M. ; Greenberg, R. S. ; Hoover, R. N. ; Hayes, R. B. ; Ziegler, R. G. / Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. In: American Journal of Epidemiology. 2002 ; Vol. 155, No. 11. pp. 1023-1032.
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