Serum, renal, and urinary lysozyme levels after hypophysectomy

Andrew Evan, R. Mollica, S. Solomon

Research output: Contribution to journalArticle

Abstract

Hypophysectomy is known to cause a rise in the renal lysozyme level and atrophy of the proximal tubules of the kidney. The present study describes the relation of serum, urinary, and renal lysozyme levels in hypophysectomized animals. The renal lysozyme level continued to rise during the first 4 weeks after hypophysectomy and then remained constant while the serum level increased immediately after hypophysectomy and plateaued. Hypophysectomy did not produce lysozymuria for the time periods used in these experiments despite obvious tubular atrophy by the end of the 1st week after hypophysectomy. These data suggest that tubular atrophy must progress to a severe stage before a lysozymuria is produced. Thus the absence of urinary lysozyme activity does not exclude the possibility of proximal tubule injury.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalInvestigative Urology
Volume13
Issue number2
StatePublished - 1975
Externally publishedYes

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Hypophysectomy
Muramidase
Kidney
Atrophy
Serum
Proximal Kidney Tubule
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serum, renal, and urinary lysozyme levels after hypophysectomy. / Evan, Andrew; Mollica, R.; Solomon, S.

In: Investigative Urology, Vol. 13, No. 2, 1975, p. 97-103.

Research output: Contribution to journalArticle

Evan, A, Mollica, R & Solomon, S 1975, 'Serum, renal, and urinary lysozyme levels after hypophysectomy', Investigative Urology, vol. 13, no. 2, pp. 97-103.
Evan, Andrew ; Mollica, R. ; Solomon, S. / Serum, renal, and urinary lysozyme levels after hypophysectomy. In: Investigative Urology. 1975 ; Vol. 13, No. 2. pp. 97-103.
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