Serum vitamin E levels in the very low birth weight infant during oral supplementation

P. R. Neal, P. Erickson, J. C. Baenziger, J. Olson, J. A. Lemons

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Abstract

A prospective study was initiated to monitor serum tocopherol levels in all infants admitted to Indiana University Medical Center with birth weights < 1,500 g. These infants routinely receive 100 mg/kg/d of oral vitamin E (Aquasol E tocopherol acetate) every six hours. Levels are determined weekly or semiweekly using a modification of the fluorometric method of Hanson and Warwick. Vitamin E dosage is adjusted regularly to achieve levels ≥ 3.5 mg/dL. During the 6 months of this study, a total of 76 patients had 567 serum measurements. Of these, 220 levels (38%) were ≥ 3.5 mg/dL, 71 (13%) were ≥ 5.5 mg/dL, and 15 (2.7%) were > 8 mg/dL. Serum tocopherol levels often (1) remained ≥ 3.5 mg/dL for several days after oral supplementation was discontinued or (2) again became ≥ 3.5 mg/dL on a reduced dosage of 25 to 50 mg/kg/d. These data indicate that infants weighing < 1,500 at birth who are receiving oral vitamin E supplementation at 100 mg/kg/d will have varied serum levels with a significant percentage exceeding 3.5 mg/dL.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalPediatrics
Volume77
Issue number5
StatePublished - Jul 16 1986

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Neal, P. R., Erickson, P., Baenziger, J. C., Olson, J., & Lemons, J. A. (1986). Serum vitamin E levels in the very low birth weight infant during oral supplementation. Pediatrics, 77(5), 636-640.