SET7/9 enzyme regulates cytokine-induced expression of inducible nitric-oxide synthase through methylation of Lysine 4 at histone 3 in the islet β cell

Kyoko Fujimaki, Takeshi Ogihara, David L. Morris, Hisanobu Oda, Hitoshi Iida, Yoshio Fujitani, Raghavendra G. Mirmira, Carmella Evans-Molina, Hirotaka Watada

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: SET7/9 regulates expression of NF-κ B target genes in non-β cells. Results: SET7/9 knockdown attenuated cytokine-induced expression of inducible nitric-oxide synthase and apoptosis in β cells. Conclusion: SET7/9 regulates Nos2 expression through methylation of H3K4 in β cells. Significance: SET7/9 contributes to proinflammatory cytokine signaling in the pancreati β cell.

Original languageEnglish (US)
Pages (from-to)16607-16618
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
StatePublished - Jul 3 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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