Severe infantile hypercalcemia associated with williams syndrome successfully treated with intravenously administered pamidronate

Andrew P. Cagle, Steven G. Waguespack, Bruce A. Buckingham, R. Ravi Shankar, Linda A. Dimeglio

Research output: Contribution to journalArticle

39 Scopus citations


Infantile hypercalcemia occurs in ∼15% of children with Williams syndrome (WS) and is typically not clinically severe. We report on 3 children with WS (confirmed with fluorescent in situ hybridization probes) who presented with severe symptomatic hypercalcemia. The first patient's severe hypercalcemia resolved with traditional therapies, whereas the subsequent 2 patients were treated with intravenously administered pamidronate after traditional measures proved only partially successful. Besides asymptomatic mild hypocalcemia, there were no complications resulting from pamidronate administration. We conclude that WS-associated hypercalcemia can be quite severe and symptomatic and that it can be successfully and safely treated with intravenously administered bisphosphonate in some cases.

Original languageEnglish (US)
Pages (from-to)1091-1095
Number of pages5
Issue number4
StatePublished - Oct 1 2004



  • Bisphosphonate
  • Hypercalcemia
  • Pamidronate
  • Williams syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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