Severe liver injury after initiating therapy with atomoxetine in two children

Joel R. Lim, Philip R. Faught, Naga P. Chalasani, Jean P. Molleston

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Two children presented with acute hepatitis after starting therapy with atomoxetine (Strattera®). In one child, no competing diagnosis could be identified, and liver injury resolved completely on withdrawal of the medication. In the second child, the evaluation was suggestive of type 1 autoimmune hepatitis; she subsequently improved with removal of atomoxetine and concomitant immunosuppressive therapy. Atomoxetine may cause clinically significant hepatotoxicity either by metabolic idiosyncrasy or by inducing autoimmune hepatitis.

Original languageEnglish (US)
Pages (from-to)831-834
Number of pages4
JournalJournal of Pediatrics
Volume148
Issue number6
DOIs
StatePublished - Jun 1 2006

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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