Sex-limited genetic variation in a mouse salivary protein

Robert C. Karn, Stephen Dlouhy, Kenneth R. Springer, J. Peter Hjorth, J. Tønnes Nielsen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.

Original languageEnglish
Pages (from-to)493-504
Number of pages12
JournalBiochemical Genetics
Volume20
Issue number5-6
DOIs
StatePublished - Jun 1982

Fingerprint

Salivary Proteins and Peptides
genetic variation
phenotype
Phenotype
saliva
protein
gender
mice
puberty
Puberty
Saliva
androgen
proteins
Androgens
androgens
Genes
Electrophoretic mobility
Genetic Crosses
gene
structural genes

Keywords

  • electrophoresis
  • mouse salivary proteins
  • sex-limited variation
  • testosterone

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

Karn, R. C., Dlouhy, S., Springer, K. R., Hjorth, J. P., & Nielsen, J. T. (1982). Sex-limited genetic variation in a mouse salivary protein. Biochemical Genetics, 20(5-6), 493-504. https://doi.org/10.1007/BF00484700

Sex-limited genetic variation in a mouse salivary protein. / Karn, Robert C.; Dlouhy, Stephen; Springer, Kenneth R.; Hjorth, J. Peter; Nielsen, J. Tønnes.

In: Biochemical Genetics, Vol. 20, No. 5-6, 06.1982, p. 493-504.

Research output: Contribution to journalArticle

Karn, RC, Dlouhy, S, Springer, KR, Hjorth, JP & Nielsen, JT 1982, 'Sex-limited genetic variation in a mouse salivary protein', Biochemical Genetics, vol. 20, no. 5-6, pp. 493-504. https://doi.org/10.1007/BF00484700
Karn, Robert C. ; Dlouhy, Stephen ; Springer, Kenneth R. ; Hjorth, J. Peter ; Nielsen, J. Tønnes. / Sex-limited genetic variation in a mouse salivary protein. In: Biochemical Genetics. 1982 ; Vol. 20, No. 5-6. pp. 493-504.
@article{1d42657a63d54a568b87c8984e42f405,
title = "Sex-limited genetic variation in a mouse salivary protein",
abstract = "This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.",
keywords = "electrophoresis, mouse salivary proteins, sex-limited variation, testosterone",
author = "Karn, {Robert C.} and Stephen Dlouhy and Springer, {Kenneth R.} and Hjorth, {J. Peter} and Nielsen, {J. T{\o}nnes}",
year = "1982",
month = "6",
doi = "10.1007/BF00484700",
language = "English",
volume = "20",
pages = "493--504",
journal = "Biochemical Genetics",
issn = "0006-2928",
publisher = "Springer New York",
number = "5-6",

}

TY - JOUR

T1 - Sex-limited genetic variation in a mouse salivary protein

AU - Karn, Robert C.

AU - Dlouhy, Stephen

AU - Springer, Kenneth R.

AU - Hjorth, J. Peter

AU - Nielsen, J. Tønnes

PY - 1982/6

Y1 - 1982/6

N2 - This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.

AB - This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.

KW - electrophoresis

KW - mouse salivary proteins

KW - sex-limited variation

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=0019943934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019943934&partnerID=8YFLogxK

U2 - 10.1007/BF00484700

DO - 10.1007/BF00484700

M3 - Article

C2 - 7115283

AN - SCOPUS:0019943934

VL - 20

SP - 493

EP - 504

JO - Biochemical Genetics

JF - Biochemical Genetics

SN - 0006-2928

IS - 5-6

ER -