Sex-limited genetic variation in a mouse salivary protein

Robert C. Karn, Stephen R. Dlouhy, Kenneth R. Springer, J. Peter Hjorth, J. Tønnes Nielsen

Research output: Contribution to journalArticle

12 Scopus citations


This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS and SspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.

Original languageEnglish (US)
Pages (from-to)493-504
Number of pages12
JournalBiochemical Genetics
Issue number5-6
StatePublished - Jun 1 1982


  • electrophoresis
  • mouse salivary proteins
  • sex-limited variation
  • testosterone

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Fingerprint Dive into the research topics of 'Sex-limited genetic variation in a mouse salivary protein'. Together they form a unique fingerprint.

  • Cite this

    Karn, R. C., Dlouhy, S. R., Springer, K. R., Hjorth, J. P., & Nielsen, J. T. (1982). Sex-limited genetic variation in a mouse salivary protein. Biochemical Genetics, 20(5-6), 493-504.