Sex, plasma prolactin and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) predict heritable d-amphetamine excitation in man

E. S. Gershon, J. I. Nurnberger, D. C. Jimerson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Behavioral responses to 0.3 mg/kg i.v. d-amphetamine were studied in a series of 13 monozygotic twin pairs, using a double-blind randomized crossover design of active drug and placebo injections. Two independent behavioral responses which we termed "excitation" and "elation" were concordant in twin pairs And reproducible within individuals. Elation was correlated with plasma amphetamine levels, but excitation was not. Higher excitation was predicted by male sex, lower pre-drug plasma prolactin, and higher pre-drug total plasma MHPG. Growth hormone response after amphetamine was greater in persons with higher excitation scores. All the biological measures but pre-drug prolactin were concordant in twin pairs. These data may imply higher activity of norepinephrine and dopamine in persons with high excitation response. Neurochemical differences between the sexes are also implied.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalAdvances in the Biosciences
Volume31
Issue numberC
StatePublished - Dec 1 1981
Externally publishedYes

Keywords

  • 3-methoxy-4-hydroxyphenylglycol
  • behavior
  • d-amphetamine
  • genetics
  • human monozygotic twins
  • prolactin

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