Sex steroids and stem cell function

Rinki Ray, Nathan M. Novotny, Paul R. Crisostomo, Tim Lahm, Aaron Abarbanell, Daniel R. Meldrum

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

Gender dimorphisms exist in the pathogenesis of a variety of cardiovascular, cardiopulmonary, neurodegenerative, and endocrine disorders. Estrogens exert immense influence on myocardial remodeling following ischemic insult, partially through paracrine growth hormone production by bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells. Estrogens also facilitate the mobilization of endothelial progenitor cells to the ischemic myocardium and enhance neovascularization at the ischemic border zone. Moreover, estrogens limit pathological myocardial remodeling through the inhibitory effects on the proliferation of the cardiac fibroblasts. Androgens also may stimulate endothelial progenitor cell migration from the bone marrow, yet the larger role of androgens in disease pathogenesis is not well characterized. The beneficial effects of sex steroids include alteration of lipid metabolism in preadipocytes, modulation of bone metabolism and skeletal maturation, and prevention of osteoporosis through their effects on osteogenic precursors. In an example of sex steroid-specific effects, neural stem cells exhibit enhanced proliferation in response to estrogens, whereas androgens mediate inhibitory effects on their proliferation. Although stem cells can offer significant therapeutic benefits in various cardiovascular, neurodegenerative, endocrine disorders, and disorders of bone metabolism, a greater understanding of sex hormones on diverse stem cell populations is required to improve their ultimate clinical efficacy. In this review, we focus on the effects of estrogen and testosterone on various stem and progenitor cell types, and their relevant intracellular mechanisms.

Original languageEnglish (US)
Pages (from-to)493-501
Number of pages9
JournalMolecular Medicine
Volume14
Issue number7-8
DOIs
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Ray, R., Novotny, N. M., Crisostomo, P. R., Lahm, T., Abarbanell, A., & Meldrum, D. R. (2008). Sex steroids and stem cell function. Molecular Medicine, 14(7-8), 493-501. https://doi.org/10.2119/2008-00004.Ray