Sex steroids and stem cell function

Rinki Ray, Nathan M. Novotny, Paul R. Crisostomo, Tim Lahm, Aaron Abarbanell, Daniel R. Meldrum

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Gender dimorphisms exist in the pathogenesis of a variety of cardiovascular, cardiopulmonary, neurodegenerative, and endocrine disorders. Estrogens exert immense influence on myocardial remodeling following ischemic insult, partially through paracrine growth hormone production by bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells. Estrogens also facilitate the mobilization of endothelial progenitor cells to the ischemic myocardium and enhance neovascularization at the ischemic border zone. Moreover, estrogens limit pathological myocardial remodeling through the inhibitory effects on the proliferation of the cardiac fibroblasts. Androgens also may stimulate endothelial progenitor cell migration from the bone marrow, yet the larger role of androgens in disease pathogenesis is not well characterized. The beneficial effects of sex steroids include alteration of lipid metabolism in preadipocytes, modulation of bone metabolism and skeletal maturation, and prevention of osteoporosis through their effects on osteogenic precursors. In an example of sex steroid-specific effects, neural stem cells exhibit enhanced proliferation in response to estrogens, whereas androgens mediate inhibitory effects on their proliferation. Although stem cells can offer significant therapeutic benefits in various cardiovascular, neurodegenerative, endocrine disorders, and disorders of bone metabolism, a greater understanding of sex hormones on diverse stem cell populations is required to improve their ultimate clinical efficacy. In this review, we focus on the effects of estrogen and testosterone on various stem and progenitor cell types, and their relevant intracellular mechanisms.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalMolecular Medicine
Volume14
Issue number7-8
DOIs
StatePublished - Jul 2008

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Estrogens
Stem Cells
Steroids
Androgens
Neurodegenerative Diseases
Bone Marrow
Bone and Bones
Neural Stem Cells
Gonadal Steroid Hormones
Mesenchymal Stromal Cells
Lipid Metabolism
Growth Hormone
Osteoporosis
Cell Movement
Testosterone
Myocardium
Fibroblasts
Population
Endothelial Progenitor Cells
Therapeutics

ASJC Scopus subject areas

  • Genetics

Cite this

Ray, R., Novotny, N. M., Crisostomo, P. R., Lahm, T., Abarbanell, A., & Meldrum, D. R. (2008). Sex steroids and stem cell function. Molecular Medicine, 14(7-8), 493-501. https://doi.org/10.2119/2008-00004.Ray

Sex steroids and stem cell function. / Ray, Rinki; Novotny, Nathan M.; Crisostomo, Paul R.; Lahm, Tim; Abarbanell, Aaron; Meldrum, Daniel R.

In: Molecular Medicine, Vol. 14, No. 7-8, 07.2008, p. 493-501.

Research output: Contribution to journalArticle

Ray, R, Novotny, NM, Crisostomo, PR, Lahm, T, Abarbanell, A & Meldrum, DR 2008, 'Sex steroids and stem cell function', Molecular Medicine, vol. 14, no. 7-8, pp. 493-501. https://doi.org/10.2119/2008-00004.Ray
Ray R, Novotny NM, Crisostomo PR, Lahm T, Abarbanell A, Meldrum DR. Sex steroids and stem cell function. Molecular Medicine. 2008 Jul;14(7-8):493-501. https://doi.org/10.2119/2008-00004.Ray
Ray, Rinki ; Novotny, Nathan M. ; Crisostomo, Paul R. ; Lahm, Tim ; Abarbanell, Aaron ; Meldrum, Daniel R. / Sex steroids and stem cell function. In: Molecular Medicine. 2008 ; Vol. 14, No. 7-8. pp. 493-501.
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