Sex steroids, bone mass, and bone loss: A prospective study of pre-, peri-, and postmenopausal women

Charles Slemenda, Christopher Longcope, Munro Peacock, Siu Hui, C. Conrad Johnston

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Although bone loss around the time of menopause is driven by estrogen deficiency, the roles of estrogens and androgens in the preservation of skeletal mass at other stages of life are less well understood. To address this issue we studied 231 women between the ages of 32 and 77 with multiple measurements of sex steroids and bone mass over a period of 2-8 yr. In all women bone mass was negatively associated with concentrations of sex-hormone binding globulin, and positively associated with weight. Bone loss occurred from all skeletal sites in peri- and postmenopausal women, but premenopausal women lost bone only from the hip (-0.3%/yr) and had positive rates of change in the radius and spine. Bone loss was significantly associated with lower androgen concentrations in premenopausal women, and with lower estrogens and androgens in peri- and postmenopausal women. Sex steroids are important for the maintenance of skeletal integrity before menopause, and for as long as 20-25 yr afterwards.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalJournal of Clinical Investigation
Volume97
Issue number1
StatePublished - Jan 1 1996

Fingerprint

Steroids
Prospective Studies
Bone and Bones
Androgens
Estrogens
Menopause
Pelvic Bones
Sex Hormone-Binding Globulin
Spine
Maintenance
Weights and Measures

Keywords

  • Androgens
  • Estrogens
  • Menopause
  • Osteocalcin
  • Sex-hormone binding globulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sex steroids, bone mass, and bone loss : A prospective study of pre-, peri-, and postmenopausal women. / Slemenda, Charles; Longcope, Christopher; Peacock, Munro; Hui, Siu; Johnston, C. Conrad.

In: Journal of Clinical Investigation, Vol. 97, No. 1, 01.01.1996, p. 14-21.

Research output: Contribution to journalArticle

Slemenda, Charles ; Longcope, Christopher ; Peacock, Munro ; Hui, Siu ; Johnston, C. Conrad. / Sex steroids, bone mass, and bone loss : A prospective study of pre-, peri-, and postmenopausal women. In: Journal of Clinical Investigation. 1996 ; Vol. 97, No. 1. pp. 14-21.
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