SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation

Mark S. McMahon, Yasuyoshi Ueki

Research output: Contribution to journalArticle

Abstract

The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.

Original languageEnglish (US)
Pages (from-to)49-50
Number of pages2
JournalHSS Journal
Volume5
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Fingerprint

Macrophage Colony-Stimulating Factor
src Homology Domains
Osteoclasts
Carrier Proteins
Macrophages
Tumor Necrosis Factor-alpha
Macrophage Colony-Stimulating Factor Receptors
RANK Ligand
Osteogenesis
Monocytes
Bone Marrow
Proteins
Therapeutics

Keywords

  • M-CSF
  • Macrophage
  • Osteoclast
  • RANKL
  • SH3BP2

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation. / McMahon, Mark S.; Ueki, Yasuyoshi.

In: HSS Journal, Vol. 5, No. 1, 01.02.2009, p. 49-50.

Research output: Contribution to journalArticle

@article{9c6e503ee6ba4af7888f24d683443f8b,
title = "SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation",
abstract = "The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.",
keywords = "M-CSF, Macrophage, Osteoclast, RANKL, SH3BP2",
author = "McMahon, {Mark S.} and Yasuyoshi Ueki",
year = "2009",
month = "2",
day = "1",
doi = "10.1007/s11420-008-9091-6",
language = "English (US)",
volume = "5",
pages = "49--50",
journal = "HSS Journal",
issn = "1556-3316",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation

AU - McMahon, Mark S.

AU - Ueki, Yasuyoshi

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.

AB - The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.

KW - M-CSF

KW - Macrophage

KW - Osteoclast

KW - RANKL

KW - SH3BP2

UR - http://www.scopus.com/inward/record.url?scp=60349090316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60349090316&partnerID=8YFLogxK

U2 - 10.1007/s11420-008-9091-6

DO - 10.1007/s11420-008-9091-6

M3 - Article

C2 - 18953613

AN - SCOPUS:60349090316

VL - 5

SP - 49

EP - 50

JO - HSS Journal

JF - HSS Journal

SN - 1556-3316

IS - 1

ER -