SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation

Mark S. McMahon, Yasuyoshi Ueki

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.

Original languageEnglish (US)
Pages (from-to)49-50
Number of pages2
JournalHSS Journal
Volume5
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • M-CSF
  • Macrophage
  • Osteoclast
  • RANKL
  • SH3BP2

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation'. Together they form a unique fingerprint.

  • Cite this