Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Nicholas Ferrell, Ruben M. Sandoval, Aihua Bian, Silvia Campos-Bilderback, Bruce Molitoris, William H. Fissell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Loss of significant functional renal mass results in compensatory structural and hemodynamic adaptations in the nephron. While these changes have been characterized in several injury models, how they affect hemodynamic forces at the glomerular capillary wall has not been adequately characterized, despite their potential physiological significance. Therefore, we used intravital multiphoton microscopy to measure the velocity of red blood cells in individual glomerular capillaries of normal rats and rats subjected to 5⁄6 nephrectomy. Glomerular capillary blood flow rate and wall shear stress were then estimated using previously established experimental and mathematical models to account for changes in hematocrit and blood rheology in small vessels. We found little change in the hemodynamic parameters in glomerular capillaries immediately following injury. At 2 wk postnephrectomy, significant changes in individual capillary blood flow velocity and volume flow rate were present. Despite these changes, estimated capillary wall shear stress was unchanged. This was a result of an increase in capillary diameter and changes in capillary blood rheology in nephrectomized rats.

Original languageEnglish
Pages (from-to)F588-F593
JournalAmerican Journal of Physiology - Renal Physiology
Volume308
Issue number6
DOIs
StatePublished - Mar 15 2015

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Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
Nephrons
Wounds and Injuries
Hematocrit
Erythrocytes
Kidney

Keywords

  • 5⁄6 nephrectomy
  • Glomerular capillary
  • Hemodynamics
  • Shear stress

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy. / Ferrell, Nicholas; Sandoval, Ruben M.; Bian, Aihua; Campos-Bilderback, Silvia; Molitoris, Bruce; Fissell, William H.

In: American Journal of Physiology - Renal Physiology, Vol. 308, No. 6, 15.03.2015, p. F588-F593.

Research output: Contribution to journalArticle

Ferrell, Nicholas ; Sandoval, Ruben M. ; Bian, Aihua ; Campos-Bilderback, Silvia ; Molitoris, Bruce ; Fissell, William H. / Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy. In: American Journal of Physiology - Renal Physiology. 2015 ; Vol. 308, No. 6. pp. F588-F593.
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