Shock wave lithotripsy adversely effects renal hemodynamics adversh y effects renal hemodynamics and iubular function in con1raeaterae (untreated) kidneys fol; owing swl treatment. b.a

Connors A.P. Evan, V. Nestmoreland, L. R. Mills, J. A. Lingeman

Research output: Contribution to journalArticle

Abstract

[his study tests the hypothesis that SWL to one kidney 'r:gt>t> influences the renal -unction in the contralateral - ]>"! i kidney. Pigs of compar-ible age (/ weeks), body and kidney weight- were divided into 3 groups. Group 1 (sham) received ni> Si-.l Group ? "-eceived 2QQO shocks (24 kV) to the right iowoi pole caiy. Group 3 received 2000 shocks to each pole of or'e kidney (right) during une treatment session. Inulin .U'd'anie (GFRi p aminohippurat.e clearances (CPW) and PAH were measun-d 1 tir before, and 1 and 4 hrs G'R. C,;.t. and (..,. were un; nanqed in Group 1. In Group 2. the '-omralateral anil shocked kidneys had reduced (p<0.05) GFK. i...... and F.,.,. In Group 3. both kidneys had reduced ip-0 !!'.) GFR. CL.M ana L. and GFR was lower than Group 2. >'.ii reduces GfR. tubular PAH extraction and CPAH in kidney contracterai to the kidney being treated. The reduction appears 10 increase a5 treatment parameters increase It is not known if the contracterai effect is due U- c 'T.ulating vasoconstrictors released by the treated kidney or is of neuronal origin.

Original languageEnglish (US)
Pages (from-to)A375
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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