Short-term memory and electrical restitution in the canine transmural ventricle

Hong Zhang, Takeshi Ueyama, Juan Wang, Rui Juan Wu, Shien-Fong Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cardiac short-term memory is an intrinsic property of paced myocardium that reflects the influence of pacing history. Using an optical mapping method to record membrane voltage and intracellular calcium (Ca2+i), this study investigated the properties and mechanisms of short-term memory in isolated and perfused canine wedge preparations. In addition to the dynamic and S1S2 pacing protocols, a perturbed downsweep pacing protocol was used to get a complete overview of the restitution portrait. Abrupt changes in basic cycle length (BCL) were applied to investigate the accommodation process of action potential duration (APD). The results showed unobvious differences of memory among the epi-, mid-and endo-myocytes, implying an insignificant memoryinduced transient heterogeneity in APD across the transmural canine hearts. With the decrease of pacing rate S1, memory gradually elevated and achieved a maximum around 400 ms, and then reduced as S1 decreased further, indicating a non-monotonic relationship between memory and the pacing rate. After suppressing the Ca2+i transient with ryanodine (3 μmol l -1), the accommodation process of APD to a new BCL significantly abbreviated (τ = 37.41 ± 4.42 stimuli before ryanodine, τ = 15.84 ± 4.74 stimuli after ryanodine, p < 0.01). Therefore, Ca 2+i cycling was suggested to play an important role in memory during dynamic pacing.

Original languageEnglish
Pages (from-to)207-222
Number of pages16
JournalPhysiological Measurement
Volume32
Issue number2
DOIs
StatePublished - Feb 2011

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Short-Term Memory
Ryanodine
Canidae
Action Potentials
Data storage equipment
Intracellular Membranes
Muscle Cells
Myocardium
History
Calcium
Membranes
Electric potential

Keywords

  • Alternans
  • Arrhythmia
  • Ca transient
  • Optical mapping
  • Restitution portrait
  • Short-term memory

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Physiology (medical)

Cite this

Short-term memory and electrical restitution in the canine transmural ventricle. / Zhang, Hong; Ueyama, Takeshi; Wang, Juan; Wu, Rui Juan; Lin, Shien-Fong.

In: Physiological Measurement, Vol. 32, No. 2, 02.2011, p. 207-222.

Research output: Contribution to journalArticle

Zhang, Hong ; Ueyama, Takeshi ; Wang, Juan ; Wu, Rui Juan ; Lin, Shien-Fong. / Short-term memory and electrical restitution in the canine transmural ventricle. In: Physiological Measurement. 2011 ; Vol. 32, No. 2. pp. 207-222.
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