Should a biologic marker be sensitive and specific?

Research output: Contribution to journalReview article

20 Scopus citations


Potential biologic markers in psychiatry are often subjected to tests of sensitivity and specificity. However, in many instances, clinically diagnosed diseases may not be truly singular in their pathophysiology, and these tests may be inappropriate. One may distinguish between diagnostic markers useful in clinical pathology, linkage markers specifying genetic location and pathophysiologic markers that are primarily vulnerable as research tools. The latter are probably most useful in present-day psychiatry but they may not be sensitive or specific in their correspondence to clinical diagnosis.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - Jul 1992


  • biologic marker
  • diagnosis
  • sensitivity
  • specificity

ASJC Scopus subject areas

  • Psychiatry and Mental health

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