Should a biologic marker be sensitive and specific?

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Potential biologic markers in psychiatry are often subjected to tests of sensitivity and specificity. However, in many instances, clinically diagnosed diseases may not be truly singular in their pathophysiology, and these tests may be inappropriate. One may distinguish between diagnostic markers useful in clinical pathology, linkage markers specifying genetic location and pathophysiologic markers that are primarily vulnerable as research tools. The latter are probably most useful in present-day psychiatry but they may not be sensitive or specific in their correspondence to clinical diagnosis.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalActa Psychiatrica Scandinavica
Volume86
Issue number1
StatePublished - 1992

Fingerprint

Psychiatry
Biomarkers
Clinical Pathology
Genetic Markers
Sensitivity and Specificity
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Should a biologic marker be sensitive and specific? / Nurnberger, John.

In: Acta Psychiatrica Scandinavica, Vol. 86, No. 1, 1992, p. 1-4.

Research output: Contribution to journalArticle

@article{4879ea910e904a019b3556f77faf77db,
title = "Should a biologic marker be sensitive and specific?",
abstract = "Potential biologic markers in psychiatry are often subjected to tests of sensitivity and specificity. However, in many instances, clinically diagnosed diseases may not be truly singular in their pathophysiology, and these tests may be inappropriate. One may distinguish between diagnostic markers useful in clinical pathology, linkage markers specifying genetic location and pathophysiologic markers that are primarily vulnerable as research tools. The latter are probably most useful in present-day psychiatry but they may not be sensitive or specific in their correspondence to clinical diagnosis.",
author = "John Nurnberger",
year = "1992",
language = "English",
volume = "86",
pages = "1--4",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Should a biologic marker be sensitive and specific?

AU - Nurnberger, John

PY - 1992

Y1 - 1992

N2 - Potential biologic markers in psychiatry are often subjected to tests of sensitivity and specificity. However, in many instances, clinically diagnosed diseases may not be truly singular in their pathophysiology, and these tests may be inappropriate. One may distinguish between diagnostic markers useful in clinical pathology, linkage markers specifying genetic location and pathophysiologic markers that are primarily vulnerable as research tools. The latter are probably most useful in present-day psychiatry but they may not be sensitive or specific in their correspondence to clinical diagnosis.

AB - Potential biologic markers in psychiatry are often subjected to tests of sensitivity and specificity. However, in many instances, clinically diagnosed diseases may not be truly singular in their pathophysiology, and these tests may be inappropriate. One may distinguish between diagnostic markers useful in clinical pathology, linkage markers specifying genetic location and pathophysiologic markers that are primarily vulnerable as research tools. The latter are probably most useful in present-day psychiatry but they may not be sensitive or specific in their correspondence to clinical diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=0026742208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026742208&partnerID=8YFLogxK

M3 - Article

C2 - 1414393

AN - SCOPUS:0026742208

VL - 86

SP - 1

EP - 4

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 1

ER -