Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet?

Kara L. Kliewer, Carina Venter, Alison M. Cassin, J. Pablo Abonia, Seema S. Aceves, Peter A. Bonis, Evan S. Dellon, Gary W. Falk, Glenn T. Furuta, Nirmala Gonsalves, Sandeep Gupta, Ikuo Hirano, Amir Kagalwalla, John Leung, Vincent A. Mukkada, Jonathan M. Spergel, Marc E. Rothenberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Eosinophilic esophagitis (EoE), a food antigen-mediated disease, is effectively treated with the dietary elimination of 6 foods commonly associated with food allergies (milk, wheat, egg, soy, tree nuts/peanuts, and fish/shellfish). Because wheat shares homologous proteins (including gluten) with barley and rye and can also be processed with these grains, some clinicians have suggested that barley and rye might also trigger EoE as a result of cross-reaction and/or cross-contamination with wheat. In this article, we discuss the theoretical risks of cross-reactivity and cross-contamination among wheat, barley, and rye proteins (including gluten); assess common practices at EoE treatment centers; and provide recommendations for dietary treatment and future studies of EoE.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
DOIs
StateAccepted/In press - Jul 31 2015

Fingerprint

Eosinophilic Esophagitis
Glutens
Hordeum
Triticum
Diet
Food
Shellfish
Nuts
Food Hypersensitivity
Cross Reactions
Ovum
Fishes
Milk
Antigens
Secale

Keywords

  • 6-food elimination diet
  • Cross-reactivity
  • Eosinophilic esophagitis
  • Gluten
  • Wheat

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kliewer, K. L., Venter, C., Cassin, A. M., Abonia, J. P., Aceves, S. S., Bonis, P. A., ... Rothenberg, M. E. (Accepted/In press). Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet? Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2015.10.040

Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet? / Kliewer, Kara L.; Venter, Carina; Cassin, Alison M.; Abonia, J. Pablo; Aceves, Seema S.; Bonis, Peter A.; Dellon, Evan S.; Falk, Gary W.; Furuta, Glenn T.; Gonsalves, Nirmala; Gupta, Sandeep; Hirano, Ikuo; Kagalwalla, Amir; Leung, John; Mukkada, Vincent A.; Spergel, Jonathan M.; Rothenberg, Marc E.

In: Journal of Allergy and Clinical Immunology, 31.07.2015.

Research output: Contribution to journalArticle

Kliewer, KL, Venter, C, Cassin, AM, Abonia, JP, Aceves, SS, Bonis, PA, Dellon, ES, Falk, GW, Furuta, GT, Gonsalves, N, Gupta, S, Hirano, I, Kagalwalla, A, Leung, J, Mukkada, VA, Spergel, JM & Rothenberg, ME 2015, 'Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet?', Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2015.10.040
Kliewer, Kara L. ; Venter, Carina ; Cassin, Alison M. ; Abonia, J. Pablo ; Aceves, Seema S. ; Bonis, Peter A. ; Dellon, Evan S. ; Falk, Gary W. ; Furuta, Glenn T. ; Gonsalves, Nirmala ; Gupta, Sandeep ; Hirano, Ikuo ; Kagalwalla, Amir ; Leung, John ; Mukkada, Vincent A. ; Spergel, Jonathan M. ; Rothenberg, Marc E. / Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet?. In: Journal of Allergy and Clinical Immunology. 2015.
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